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| 他汀联合烟酸类药物的临床试验评价 | |
| 引用本文： | 严晓伟. 他汀联合烟酸类药物的临床试验评价[J]. 中国新药杂志, 2011, 0(15) |
| 作者姓名： | 严晓伟 |
| 作者单位： | 中国医学科学院北京协和医学院北京协和医院心内科; |
| 摘 要： | 在他汀治疗使低密度脂蛋白胆固醇(LDL-C)达标的后,对高密度脂蛋白胆固醇(HDL-C)降低的患者加用烟酸,可以升高HDL-C并降低甘油三酯,显著改善血脂谱。尽管小规模临床试验显示在他汀基础上联合烟酸可以延缓冠状动脉斑块或颈动脉内膜中层厚度的进展,但他汀联合烟酸的疗效至今仍然没有在大规模临床试验中得到证实。单纯升高HDL-C血浆水平而不关注HDL-C的清除是目前针对HDL-C干预治疗的问题所在,他汀联合烟酸的有效性和安全性有待于进一步证实。 |
| 关 键 词： | 他汀 烟酸 临床试验 |
Combination of statin and niacin in clinical trials |
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| YAN Xiao-wei. Combination of statin and niacin in clinical trials[J]. Chinese Journal of New Drugs, 2011, 0(15) | |
| Authors: | YAN Xiao-wei |
| Affiliation: | YAN Xiao-wei(Department of Cadiology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China) |
| Abstract: | After statin treatment keeps low density lipoprotein cholesterol(LDL-C) under control,niacin can be used to raise HDL-C level,decrease triglyceride and improve lipid profile markedly.In some small studies,niacin,with the background treatment of statins,significantly attenuated the progression of coronary artery plaque or carotid intimal medial thickness.However,therapeutic efficacy of niacin has never been demonstrated in large-scale,prospective clinical trials.Raising plasma HDL-C level without paying atte... |
| Keywords: | statin niacin clinical trial |
| 本文献已被 CNKI 等数据库收录！ | |