| 天然维生素E纳米乳的制备及其性质考察 |
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| 引用本文： | 樊丽雅,郑春丽,朱家壁. 天然维生素E纳米乳的制备及其性质考察[J]. 中国新药杂志, 2011, 0(10) |
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| 作者姓名： | 樊丽雅 郑春丽 朱家壁 |
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| 作者单位： | 中国药科大学药物制剂研究所; |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX09310-004); 国家自然科学基金(30772663); 中央高校基本科研业务费专项(JKQ2009024) |
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| 摘 要： | 目的:制备天然维生素E纳米乳并对其性质进行考察。方法:通过单因素考察和正交试验设计优选天然维生素E纳米乳的制备工艺和最佳处方,并通过形态、粒径、Zeta电位、pH值的测定研究其性质。结果:天然维生素E纳米乳的最佳处方为注射用油5 g,蛋黄卵磷脂1.5 g,F68 4 g,油酸0.25 g。所制备的乳剂外观呈乳白略带黄色,有蓝色乳光,平均粒径为87.7 nm,PI为0.287,Zeta电位为-23.5 mV,pH值为6.79。结论:本实验制备的天然维生素E纳米乳符合注射用制剂的要求。
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| 关 键 词： | 天然维生素E 纳米乳 离心稳定常数 粒径 Zeta电位 |
Preparation and physicochemical property of natural vitamin E nano-emulsion |
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| FAN Li-ya,ZHENG Chun-li,ZHU Jia-bi. Preparation and physicochemical property of natural vitamin E nano-emulsion[J]. Chinese Journal of New Drugs, 2011, 0(10) |
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| Authors: | FAN Li-ya ZHENG Chun-li ZHU Jia-bi |
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| Affiliation: | FAN Li-ya,ZHENG Chun-li,ZHU Jia-bi(Pharmaceutical Research Institute,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Objective: To prepare natural vitamin E nano-emulsion and investigate its physicochemical properties.Methods: Single factor analysis and orthogonal test were designed to optimize the preparation technology and the formulation of natural vitamin E nano-emulsion.The properties of the preparation such as morphology,particle size,Zeta potential,pH value were studied.Results: The optimal formulation of natural vitamin E nano-emulsion was as follows: oil of injection was 5g,egg lecithin was 1.5g,F68 was 4g,and ol... |
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| Keywords: | natural vitamin E nano-emulsion Ke particle size Zeta potential |
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