| 葡萄内酯在小鼠体内的组织分布 |
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| 引用本文： | 袁金斌,李明,陈海芳,张瑜,刘莹莹,杨武亮. 葡萄内酯在小鼠体内的组织分布[J]. 中国新药杂志, 2011, 0(23) |
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| 作者姓名： | 袁金斌 李明 陈海芳 张瑜 刘莹莹 杨武亮 |
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| 作者单位： | 江西中医学院现代中药制剂教育部重点实验室; |
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| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX09103-350); 国家自然科学基金(30660230); 江西省卫生厅科研课题(2009A057) |
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| 摘 要： | 目的:考察灌胃给药后葡萄内酯在小鼠体内各个组织中的分布情况。方法:给药后,于不同时间点取心、肝、脾、肺、肾、脑、胃、肠、肌肉、脂肪10个组织,制成组织匀浆,用乙酸乙酯萃取富集,氮吹处理后甲醇定容,采用高效液相色谱法测定并计算各个组织中葡萄内酯的浓度。结果:给药后30 min各组织中药物浓度由高到低依次为:胃>肠>肝脏>脂肪>肾>心脏>肌肉>肺>脾>脑;给药后120 min心、肝、脾、肾、脑等组织中出现分布高峰;480 min后依次消除。结论:葡萄内酯能被迅速吸收并广泛分布到各个组织,但吸收消化的过程比较持久,能透过血脑屏障,在靶器官中的作用时间>8 h。
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| 关 键 词： | 葡萄内酯 组织分布 小鼠 高效液相色谱法 |
Tissue distribution of auraptene in mice |
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| YUAN Jin-bin,LI Ming,CHEN Hai-fang,ZHANG Yu,LIU Ying-ying,YANG Wu-liang. Tissue distribution of auraptene in mice[J]. Chinese Journal of New Drugs, 2011, 0(23) |
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| Authors: | YUAN Jin-bin LI Ming CHEN Hai-fang ZHANG Yu LIU Ying-ying YANG Wu-liang |
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| Affiliation: | YUAN Jin-bin,LI Ming,CHEN Hai-fang,ZHANG Yu,LIU Ying-ying,YANG Wu-liang(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China) |
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| Abstract: | Objective: To determine the distribution of auraptene in mouse tissues after oral adminstration.Methods: After oral administration of auraptene,the heart,liver,spleen,lungs,kidney,brain,stomach,intestine,muscle and fat tissues were isolated and homogenized.The homogenate was extracted with ethyl acetate,and evaporated to dry under nitrogen atmosphere.The contents of auraptene in various samples were determined by HPLC method.Results: At 30 min after administration,the contents of auraptene in tissues were i... |
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| Keywords: | auraptene tissue distribution mouse HPLC |
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