| 中效胰岛素联合那格列奈与预混胰岛素治疗2型糖尿病疗效比较 |
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| 引用本文： | 范慧,张鹏睿,徐援.中效胰岛素联合那格列奈与预混胰岛素治疗2型糖尿病疗效比较[J].中国新药杂志,2011(9). |
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| 作者姓名： | 范慧 张鹏睿 徐援 |
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| 作者单位： | 首都医科大学附属北京朝阳医院内分泌科; |
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| 摘 要： | 目的:预混胰岛素血糖控制不佳者改用那格列奈联合中效人胰岛素(NPH)在2型糖尿病患者中的有效性及安全性。方法:选择应用预混人胰岛素3月及以上血糖控制不佳的2型糖尿病患者108例,分为2组,一组(42例)维持原方案的基础上调整预混胰岛素用量,另一组(66例)改用那格列奈联合中效人胰岛素治疗,随访3月及6月,比较治疗前后两组空腹血糖(FBG),餐后2 h血糖(2hPBS),糖化血红蛋白(HbA1c)及低血糖发生率,体重变化情况。结果:那格列奈联合中效人胰岛素与预混胰岛素治疗3月和1年时比较,FBG、2hPBS及HbA1c较治疗前均明显下降;同时低血糖发生率减少;体重及体重指数3月后无明显变化但1年后有所降低。结论:2型糖尿病患者应用那格列奈联合中效胰岛素能更好控制血糖;同时减少低血糖的发生率,不增加体重,兼顾了治疗的有效性及安全性,疗效优于预混胰岛素。
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| 关 键 词： | 2型糖尿病 中效胰岛素 那格列奈 |
Efficacy and safety of nateglinide combined with NPH insulin compared with mexed type insulin in patients with type 2 diabetes mellitus |
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| FAN Hui,ZHANG Peng-rui,XU Yuan.Efficacy and safety of nateglinide combined with NPH insulin compared with mexed type insulin in patients with type 2 diabetes mellitus[J].Chinese Journal of New Drugs,2011(9). |
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| Authors: | FAN Hui ZHANG Peng-rui XU Yuan |
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| Institution: | FAN Hui,ZHANG Peng-rui,XU Yuan(Department of Endocrinology,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing 100020,China) |
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| Abstract: | Objective:To compare the efficacy and safety of nateglinide+NPH insulin with mixed type insulin in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 108 patients whose blood glucose poorly controlled by mixed type insulin were treated by either nateglinide+NPH insulin or mixed type insulin.During 3 and 6 months of treatment,the changes in fasting blood glucose(FBG),2-h postprandial blood glucose(PBG),glycosylated hemoglobin A1c(HbA1c) as well as body weight and hypoglycemia were recorded.Resul... |
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| Keywords: | type 2 diabetes mellitus NPH insulin nateglinide |
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