|
|||||
|
|
| 盐酸二甲双胍缓释微丸的制备及体外释放度考察 | |
| 引用本文： | 秦超,尹莉芳,王广基,许红,周建平. 盐酸二甲双胍缓释微丸的制备及体外释放度考察[J]. 中国新药杂志, 2011, 0(21) |
| 作者姓名： | 秦超 尹莉芳 王广基 许红 周建平 |
| 作者单位： | 中国药科大学药学院;中国药科大学门诊部; |
| 基金项目： | 国家“重大新药创制”科技重大专项——新制剂与新释药系统技术平台(2009ZX09310-004); 2008年度教育部新世纪优秀人才支持计划(NCET-08-0846) |
| 摘 要： | 目的:制备盐酸二甲双胍(metformin hydrochloride,MH)缓释微丸,并考察其体外释药行为。方法:通过离心造粒法制得MH微丸,以乙基纤维素水分散体(Surelease),丙烯酸树脂水分散体(EudragitNE30D,RS30D)作为膜控释包衣材料,通过流化床包衣制备MH缓释微丸,并考察不同包衣材料、包衣增重、固化时间、释放介质对释放度的影响。结果:离心造粒制得微丸圆整度好,有一定强度,适合包衣,Surelease包衣增重11%时所得的缓释微丸在12 h具有明显的缓释效果,不受释放介质的影响,为零级释放,且12 h释放可以达到85%以上。释放机制主要是通过无孔膜扩散作用。结论:通过离心造粒并用Surelease包衣的MH缓释微丸缓释效果明显,且为零级释放。 |
| 关 键 词： | 盐酸二甲双胍 离心造粒 缓释微丸 释放度 零级释放 |
Preparation and in-vitro release of metformin hydrochloride sustained-release pellets |
|
| QIN Chao,YIN Li-fang,WANG Guang-ji,XU Hong,ZHOU Jian-ping. Preparation and in-vitro release of metformin hydrochloride sustained-release pellets[J]. Chinese Journal of New Drugs, 2011, 0(21) | |
| Authors: | QIN Chao YIN Li-fang WANG Guang-ji XU Hong ZHOU Jian-ping |
| Affiliation: | QIN Chao1,YIN Li-fang1,WANG Guang-ji1,XU Hong2,ZHOU Jian-ping1(1 College of Pharmacy,2 Clinics,China Pharmaceutical University,Nanjing 210009,China) |
| Abstract: | Objective: To prepare metformin hydrochloride(MH) sustained-release pellets,and to investigate their in-vitro release behavior and the release mechanism.Methods: MH pellets were prepared by a centrifugal granulation method.Ethyl cellulose aqueous dispersion(Surelease) and acrylic polymers aqueous dispersion(Eudragit NE30D,RS30D) were used as sustained-release coating materials with fluid bed.The effects of different coating materials,coating weight,curing time and release medium on the in-vitro release were... |
| Keywords: | metformin hydrochloride centrifugal granulation sustained-release pellets release rate zero-order release |
| 本文献已被 CNKI 等数据库收录！ | |