海南地区汉族人群HLA及其单倍型频率分析

目的了解海南地区汉族人群HLA抗原及单倍型的频率。方法采用微量淋巴细胞毒试验，对海南地区209例非血缘关系的汉族正常人进行HLA-A、B抗原分型。结果在209例中检出前9位HLA-A、HIA-B高频率抗原为A11，A2，A24、A33；B40，B46，B57，B13，B62。通过家系抗原遗传分析获得418条海南地区HLA-A／B单倍型，查出6条海南地区高频率出现的单倍型为A33／B57、A2／B46、A11／B60、A11／B13、A24／B60、A11／B62。结论海南地区汉族人群的HLA-A、B抗原频率与广东地区相同，而单倍型频率有所不同。不同种族、不同地区的人群有着不同单倍型频率分布。

Analysis of HLA and its haplotype gene frequency in Han nationality in Hainan Province

Objective To study the HLA and its haplotype gene frequency in population of Hainan Province.Methods HLA-a and B typing by means of microlymphocytotoxicity test on 209 normal persons without kinship in Hainan Province was performed. Results Nine high haplotype gene frequency (HGF) antigens of HLA-A and B from 209 persons, i.e. A 11, A 2, A 24, A 33, B 40, B 46, B 57, B 13, and B62, were identified by analysis of antigen genalogy. Out of the 418 HLA-A and B haplotypes discovered in Hainan Province 6 show the highest frequency, they are A 33/B 57, A 2/B 46, A 11/B 60, A 11/B 13, A 24/B 60, A 11/B 62 Conclusion The HLA-A and B gene frequency in Hainan Province is the same as Guangdong Province but its HGF is different. Thus the distribution of HGF is different in population of different regions.