Reduced bone density in individuals with severe hemophilia B

Aim: The reduced bone density in individuals with severe hemophilia A (decreased coagulation factor VIII level) and combined factor V and VIII deficiency have been reported. In the current case‐control study we tried to address bone mineral density in individuals with severe hemophilia B (decreased coagulation factor IX). Methods: In our case‐control study, we recruited bone density and biochemical indexes in 14 individuals with severe hemophilia B and compared obtained results with 14 age‐ and sex‐matched control group results. Results: Our results showed individuals with severe hemophilia B had reduced bone density in lumbar (–0.34 ± 0.97) and femur (–0.82 ± 1.37) regions, compared to the control group (0.84 ± 0.53 and 1.02 ± 1.04 respectively; P‐value = 0.000 and 0.000). Conclusion: The foremost complication of coagulation disorders are various types of excessive bleedings. The current study revealed severe hemophiliac B patients are prone to reduced bone density similar to severe hemophiliac A patients.