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痛泻二草方对溃疡性结肠炎模型大鼠肠黏膜乳酸含量和髓过氧化物酶活性的影响
引用本文:程容 段永强 成映霞 程畅和 张元澧 杨莲莲. 痛泻二草方对溃疡性结肠炎模型大鼠肠黏膜乳酸含量和髓过氧化物酶活性的影响[J]. 兰州大学学报(医学版), 2006, 32(3): 55-57
作者姓名:程容 段永强 成映霞 程畅和 张元澧 杨莲莲
作者单位:甘肃中医学院,中医基础理论教研室,甘肃,兰州,730000;甘肃省中医学校中医基础理论教研室,甘肃,兰州,730030;甘肃省建筑职工医院,甘肃,兰州,730030
基金项目:甘肃省教育厅基金资助项目(034B-05)
摘    要:
目的 通过痛泻二草方对溃疡性结肠炎(UC)模型大鼠肠粘膜乳酸(LA)含量和髓过氧化物酶(MPO)活性的影响,探讨痛泻二草方防治UC的作用机理。方法 采用抗原免疫法和局部刺激法建立UC动物模型。将50只大鼠随机分愈合的为空白组、模型组、痛泻二草方组、痛泻要方组和补脾益肠丸组,分别对各组大鼠肠粘膜LA含量、MPO活性进行检测。结果 与空白组比较,模型组大鼠肠粘膜LA含量,MPO活性显著升高(P〈0.01,P〈0.05);经药物治疗后与模型组比较,痛泻二草方可显著降低UC模型大鼠肠粘膜LA含量和MPO活性(P〈0.05)。结论 痛泻二草方具有抑制MPO活性,减少中性粒细胞浸润和清除LA而减轻炎性反应、促进溃疡愈合的作用。

关 键 词:痛泻二草方  溃疡性结肠炎  乳酸  髓过氧化物酶
文章编号:1000-2812(2006)03-0055-03
收稿时间:2006-04-12
修稿时间:2006-04-12

Effects of Tongxieercaofang on levels of lactic acid and myeloperoxidase activity in intestinal mucosa of rats with ulcerative colitis
CHENG Rong ,DUAN Yong-qiang ,CHENG Ying-xia , CHENG Chang-he , ZHANG Yuan-li, YANG Lian-lian. Effects of Tongxieercaofang on levels of lactic acid and myeloperoxidase activity in intestinal mucosa of rats with ulcerative colitis[J]. Journal of Lanzhou University (Medical Sciences), 2006, 32(3): 55-57
Authors:CHENG Rong   DUAN Yong-qiang   CHENG Ying-xia    CHENG Chang-he    ZHANG Yuan-li   YANG Lian-lian
Affiliation:1. Department of Basical Theory of Traditional Chinese Medicin ,Gansu College of Traditional Chinese Medicine, Lanzhou , 730000, China ; 2. Department of Basical Theory of Traditional Chinese Medicin , Gansu School of Traditional Chinese Medicine ,Lanzhou , 730030, China; 3. Staff-worker Hospital of Architecture Company, Lanzhou ,730030 China
Abstract:
Objective To study effects of Tongxieercaofang(TXECF) on levels of lactic acid(LA)and myeloperoxidase(MPO) in intestinal mucosa tissue of rats with ulcerative colitis and research the mechanism of TXECF on ulcerative colitis.Methods ulcerative colitis model was established by immunization and stimulus.50 rats were divided into 5 groups randomly:normal group,model group,TXECF group,TXYF group,BPYCW group.Then we had observed the effect of TXECF on levels of LA and MPO in intestinal mucosa tissue.Results successful model group,LA and MPO in intestinal mucosa tissue were much higher than those of normal group(P<0.01,P<0.05).Compared with model group,TXECF could decrease LA and MPO in intestinal mucosa tissue(P<0.05) significantly.Conclusion It was suggested that TXECF has functions of restraining MPO activity,reducing infiltration of neutrophilic granulocyte and eliminating LA.So it could reduce inflammatory reaction and heal ulcerative colitis.
Keywords:Tongxieercaofang    ulcerative colitis    lactic acid    myeloperoxidase
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