| Anti-implantation activity of 2 derivatives of o-hydroxy naphthaquinones in rats |
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| 引用本文： | S K DHAR,Sushma MATTU. Anti-implantation activity of 2 derivatives of o-hydroxy naphthaquinones in rats[J]. Acta pharmacologica Sinica, 1995, 0(5) |
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| 作者姓名： | S K DHAR Sushma MATTU |
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| 作者单位： | Pharmacology Division，Regional Research Laboratory，Canal Road，Jammu Tawi 180 001，India，Department of Chemistry，Deshbandhu College，Kalkaji，New Delhi 110 019，India |
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| 摘 要： | AIM:To search for female contraceptive agents. METHODS: 2-Hydroxy-3-methyl-1, 4-naphthoquinone monosemicarbazone ( HMNQS ) and 2-hydroxy-1, 4-naphthoquinone monothiosemicarbazone ( HNQTS ) were screened for anti-implantation activity in rats. RESULTS: Both compounds showed a dose-dependent activity, and HNQTS was more potent. An 100 % anti-implantation activity was observed with HNQTS 150 mg kg-1 ig . Its LD50 was found to be >2g kg-1 ig in mice. CONCLUSION: HNQTS was more potent than HMNQS for anti-implantation activity in rats.
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Anti-implantation activity of 2 derivatives of o-hydroxy naphthaquinones in rats |
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| S K DHAR. Anti-implantation activity of 2 derivatives of o-hydroxy naphthaquinones in rats[J]. Acta pharmacologica Sinica, 1995, 0(5) |
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| Authors: | S K DHAR |
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| Abstract: | AIM:To search for female contraceptive agents. METHODS: 2-Hydroxy-3-methyl-1, 4-naphthoquinone monosemicarbazone ( HMNQS ) and 2-hydroxy-1, 4-naphthoquinone monothiosemicarbazone ( HNQTS ) were screened for anti-implantation activity in rats. RESULTS: Both compounds showed a dose-dependent activity, and HNQTS was more potent. An 100 % anti-implantation activity was observed with HNQTS 150 mg kg-1 ig . Its LD50 was found to be >2g kg-1 ig in mice. CONCLUSION: HNQTS was more potent than HMNQS for anti-implantation activity in rats. |
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| Keywords: | naphthoquinones synthetic oral contraceptives estrogen antagonists |
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