| 应用显微分光光度计检测大肠癌及大肠其它病——DNA含量与发病学关系的研究 |
| |
| 引用本文： | 周亚东,周殿元,续正慧,张万岱,张月彩,李树彬. 应用显微分光光度计检测大肠癌及大肠其它病——DNA含量与发病学关系的研究[J]. 癌症, 1993, 0(1) |
| |
| 作者姓名： | 周亚东 周殿元 续正慧 张万岱 张月彩 李树彬 |
| |
| 作者单位： | 第一军医大学珠江医院消化内科,第一军医大学南方医院消化内科,第一军医大学南方医院消化内,第一军医大学南方医院消化内科,第一军医大学南方医院消化内科,第一军医大学南方医院消化内科 广州 510282,广州 510282,广州 510282,广州 510282,广州 510282,广州 510282 |
| |
| 摘 要： | 应用显微分光光度计分别对大肠癌、癌旁组织、慢性结肠炎、腺瘤性息肉和几种非腺瘤性息肉标本进行DNA定量分析。结果显示所有大肠癌标本DNA含量明显高于正常粘膜、慢性结肠炎、腺瘤(伴轻、中度不典型增生)和几种非腺瘤性息肉。DNA含量在腺瘤中随不典型增生程度的加重而明显增加,支持关于“腺瘤——癌演续”的理论,且表明这一演续过程为多步骤性。而其它几种非腺瘤性息肉则未发现与大肠癌之间有明显发病学关系。
|
| 关 键 词： | 大肠癌 大肠息肉 DNA含量 |
DETERMINATION OF DNA CONTENTS IN COLORECTAL CARCINOMA AND OTHER COLORECTAL DISEASES WITH MICROSPECTR OPHOTOMETR YAND STUDY ON THEIR ETIOLOGICAL RELATIONSHIP |
| |
| ZHOU Ya-dong ZHOU Dian-yuan XU Zheng-hui ZHANG Wan-daiZHANG Yue-cai LI Shu-bin. DETERMINATION OF DNA CONTENTS IN COLORECTAL CARCINOMA AND OTHER COLORECTAL DISEASES WITH MICROSPECTR OPHOTOMETR YAND STUDY ON THEIR ETIOLOGICAL RELATIONSHIP[J]. Chinese journal of cancer, 1993, 0(1) |
| |
| Authors: | ZHOU Ya-dong ZHOU Dian-yuan XU Zheng-hui ZHANG Wan-daiZHANG Yue-cai LI Shu-bin |
| |
| Abstract: | Tissue specimens of colorectal carcinoma, mucosa adjacent to carcinoma, chronic colitis, adenoma, nan-adenomatous polypses were examined with the method of DNA quantitative analysis using microspectrophotometry: The sresults showed that the DNA contents of all specimens of colorectal carcinoma were significantly higher than those of normal colorectal mucosa, chronic colitis, adenomas (with mild, moderate dysp-lasia) and non-adenomatous polypses. The results that DNA contents increased in adenoma along with the degree of dysplasia gived a support to the theory of "adenoma-carcinoma sequence" and suggested that this sequencial procedure was of multiple-stage. No significant relationship between colorectal carcinoma and non-adenomatous polypses was found. |
| |
| Keywords: | colorectal carcinoma colorectal polyps DNA content |
| 本文献已被 CNKI 等数据库收录！ |
|
