| 海石合剂对实验性哮喘豚鼠内皮素的影响 |
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| 引用本文： | 高素军,余萍,陈陶后. 海石合剂对实验性哮喘豚鼠内皮素的影响[J]. 中国中医急症, 2002, 11(5): 381-382 |
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| 作者姓名： | 高素军 余萍 陈陶后 |
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| 作者单位： | 1. 湖北中医学院附属医院,武汉430061
2. 湖北中医学院,武汉430061 |
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| 摘 要： | 目的探讨海石合剂对支气管哮喘的作用机理。方法用卵蛋白致敏豚鼠复制急性支气管哮喘动物模型,用海石合剂治疗,观察动物血浆和支气管肺泡灌洗液(BALF)中内皮素(ET-1)水平的变化。结果实验性哮喘豚鼠发作时血浆和BALF中ET-1水平分别显著高于发作前和对照组,海石合剂对实验性哮喘豚鼠BALF中ET-1水平有明显降低作用。造模组BALF中ET-1与血栓素B2(TXB2)呈正相关关系。结论海石合剂有效治疗哮喘的作用与抑制肺系局部ET-1的产生密切相关。
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| 关 键 词： | 海石合剂 支气管哮喘 内皮素 实验研究 |
| 文章编号： | 1004-745X(2002)05-0381-02 |
| 修稿时间： | 2001-12-03 |
Experimental Study on Influence on Haishi Mixture to ET of Guiner - Pig with Asthma |
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| Gao Sujun ,Yu Ping ,Chen Taohou. Experimental Study on Influence on Haishi Mixture to ET of Guiner - Pig with Asthma[J]. Journal of Emergency in Traditional Chinese Medicine, 2002, 11(5): 381-382 |
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| Authors: | Gao Sujun Yu Ping Chen Taohou |
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| Affiliation: | Gao Sujun 1,Yu Ping 1,Chen Taohou 2 .1Affiliated Hospital of Hubei College of TCM,Wuhan |
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| Abstract: | Objective:To explore the mechanism of action of Haishi Mixture to bronchial asthma,Methods :The acute bronchial asthma animal mo del was repliated by lecithoprotein sensitized guinea -pig,and was therapied with Haishi Mixtre.The change of level of ET -1in plasma and b ronchoalveolar lavage fluid(BAIF)were observed.Results:When laboraory asthma guinea -pig at tacked,the level of ET -1in plasma and BALF was far higher than befoe attacking and controlled group,so Houishi Mixtre has remarkable lowing action to the l evel of ET -1in BALF of laboratory asthma guinea -pi g.ET -1in BALF of model group has to do with TXB 2 .Conclusion:There are close links between the action of Haishi Mxture in curing effectivly asthma and inhi biting lungs local ET -1. |
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| Keywords: | Haishi Mixture Bronchial asthma ET -1 experimen tal study(Original article on page 381) |
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