CT、磁共振定量诊断肝纤维化的研究进展

肝纤维化是肝脏对各种病因所致的肝损伤的修复愈合反应，也是各种慢性肝病向肝硬化发展的中间阶段。肝纤维化发展过程是潜隐渐进而可逆的。肝纤维化能否得到及时和正确的诊断，对临床治疗效果及患者预后有着重要的意义。随着影像技术的发展完善，肝纤维化的无创性影像定量诊断备受临床关注。总结了目前用于肝纤维化诊断的各种CT、磁共振（MR）扫描技术，就各种技术的优缺点进行了比较。结果表明CT、MR可对肝纤维化进行定量评估，尤其MR无辐射、高分辨率、可重复性好在将来完全有可能取代有创的病理检查。

Research progress in CT and MR for quantitative diagnosis of liver fibrosis

Liver fibrosis is a repair response to liver damage caused by various factors, as well as an intermediate stage between chronic liver diseases and liver cirrhosis. The development of liver fibrosis is a latent, gradual, and reversible process. Timely, accurate diagnosis of liver fibrosis is of great significance for the treatment outcome and prognosis of patients. With the development of imaging techniques, noninvasive quantitative diagnosis of liver fibrosis has attracted more and more attention. Various techniques of CT and MR for diagnosis of liver fibrosis are summarized, and the advantages and disadvantages are compared between these techniques. Our results show that CT and MR can be used for quantitative assessment of liver fibrosis and that MR is very likely to be used instead of invasive biopsy in the future due to its advan-tages of no radiation, high resolution, and good repeatability.