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| 活性氧在急性脊髓损伤中的关键作用 | |
| 引用本文： | 马爱斌,王文敏,陆地. 活性氧在急性脊髓损伤中的关键作用[J]. 医学综述, 2009, 15(12): 1781-1784 |
| 作者姓名： | 马爱斌 王文敏 陆地 |
| 作者单位： | 1. 昆明医学院第一附属医院神经内科,昆明,650032 2. 昆明医学院人体解剖学教研室,昆明,650031 |
| 摘 要： | 急性脊髓损伤(SCI)是一种常见的严重的神经功能损伤性疾病。SCI包括初始的机械性创伤和继发性损伤。一系列的病理生理机制共同促成了继发性损伤,如由出血和缺血/再灌注诱导的血管损伤效应、氨基酸的兴奋性毒性、钙超载、凋亡、线粒体功能障碍、活性氧生成等。这些因素能加重组织损伤的程度,促使损伤范围在伤后一段时间内不断扩大。在继发性损伤中关键的生化反应事件是活性氧诱导的氧化应激,鉴于其在SCI进程中的重要性,关注活性氧将有助于寻找治疗SCI的药物。 |
| 关 键 词： | 脊髓损伤 活性氧 线粒体 |
A Critical Role of Reactive Oxygen Species after Acute Spinal Cord Injury |
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| MA Ai-bin,WANG Wen-min,LU Di. A Critical Role of Reactive Oxygen Species after Acute Spinal Cord Injury[J]. Medical Recapitulate, 2009, 15(12): 1781-1784 | |
| Authors: | MA Ai-bin WANG Wen-min LU Di |
| Affiliation: | MA Ai-bin , WANG Wen- min , LU Di. ( 1. Departmera of Neurology, the First Affiliated Hospital of Kanming Medical College,Kunming 650032, China ; 2. Departrnera of Human Anatomy, Kunming Medical College, Kunming 650031, China ) |
| Abstract: | Acute spinal cord injury （SCI）is a common severe neurelogic disorder. SCI includes primary injuries that caused by mechanical forces and secondary lesions. Secondary injuries results from a cascade of pathophysiologic mechanisms such as hemorrhage and ischemic-reperfusion-induced vascular insults, amino acids-induced excitotoxicity, high concentrations of intracellular calcium, apoptosis, disturbances of mitochon- drion, generations of reactive oxygen species and so on. These factors can exacerbate tissue damage, enlarge the injury scope during some time after injury. A key biochemical event in the secondary injuries is ROS-induced oxidative stresses,which plays an important role in progression of SCI. Pay attention to ROS will facilitate the pharmacological interventions in treating acute SCI. |
| Keywords: | Spinal cord injury Reactive oxygen species Mitochondrion |
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