地尔硫卓逆转高血压左室肥厚的研究

目的 比较地尔硫卓与卡托普利对高血压左室肥厚的消退作用。方法 观察32例高血压患者口服地尔硫卓12周后左室形态结构和左室功能变化,并与34例卡托普利治疗对比。结果 地尔硫卓组与卡托普利组治疗后LVMI分别降低6.3％和17.9％(P<0.05,P<0.01),E/A比值分别升高22.3％和22.1％(P<0.01)。结论 提示两药均能逆转左室肥厚和改善左室舒张功能。卡托普利对逆转左室肥厚更具优点,并探讨其作用机制。

Effects of diltiazem on the hypertensive hypertrophy of left ventricle

Objective The aim of this study was to compare the effects of diltiazem with captopril on the regression of left ventricular hypertrophy (LVH) and function . Methods Thirty-two patients with LVH were treated with diltiazem (90 mg/d) for 12 months, and the orther 34 patients were treated with captopril (75 mg/d) for 12 months. All patients underwent echocardiography to assess left ventricular structure and function before and after the treatment. Results After the treatment, the left ventricu-lar mass index decreased significantly by 6.3% with diltiazem (P < 0.05) and by 17.9% with captopril (P < 0.01). And the E/A ratio, as an index of left ventricular diastolic function, increased significantly by 22.3% with diltiazem (P<0.01) and by 22.1% with captopril (P < 0.01), respectively. Conclusion Both diltiazem and captopril similarly reduced LVH and improved left ventricular diastolic function, however, captopril has more beneficial effects on the reversion of LVH.