利培酮对分裂症患者血清胆碱酯酶活力的影响及疗效研究

目的：探讨利培酮对分裂症患者血清胆碱酯酶活力的影响及疗效。方法：采用自身对照的方法，分别于治疗前，治疗后1、2、3、4周测血清胆碱酯酶活力，并测BPRS和TESS。结果：治疗前与治疗后1、2,3、4周血清胆碱酯酶活力的比较差异无统计学意义（p〉0．05）。治疗前与治疗后第2、4周BPRS比较差异均有显著性，t值分别为t=2．40，P〈0．02；t=5．24，P〈0．01。结论：利培酮对分裂症患者血清胆碱酯酶活力无明显影响，有显著疗效。

A comparative study of serum cholinesterase activity influence and clinicaleffect after patients take risperidone

Objectives:To determine the influence of serum cholinesterase activity and clinical effect by risperidone in schizophrenic patients. Methods:Using control-self study to determine the serum cholinesterase activity before treatment and at 1,2,3,4 weeks after treatment. BPRS and TESS were used to measure clinical effects and side effects. Results: Serum cholinesterase activity had no significant difference between before treatment and at 1,2,3,4 weeks after treatment (P>0.05). BPRS demonstrated statistics significant difference between before treatment and at 2,4 week after treatment (t=2.40, P<0.02; t=5.24, P<0.01). Conclusions: Risperidone had no significant influence on serum cholinesterase activity and had good efficacy on schizophrenic patients.