婴幼儿泪囊炎病原菌208株分布和耐药性分析

目的了解婴幼儿泪囊炎病原菌的分布及耐药情况,为临床合理用药提供依据。方法用常规方法对婴幼儿泪囊炎分泌物标本进行病原菌分离培养鉴定,用纸片扩散法（K-B法）进行药物敏感性试验,对分离出的病原菌分布及耐药性进行分析。结果共分离出非重复病原菌208株,其中革兰阴性杆菌105株占50.5%（105/208）,革兰阳性球菌100株占48.1%（100/208）,真菌3株占1.4%（3/208）。分离率居首位的为肺炎链球菌占17.3%（36/208）,其次为表皮葡萄球菌占13.0%（27/208）、肺炎克雷伯菌占10.6%（22/208）和副流感嗜血杆菌占9.6%（20/208）。氧氟沙星和左氧氟沙星对以上4种主要病原菌耐药率均〈30%。结论婴幼儿泪囊炎病原菌以肺炎链球菌、表皮葡萄球菌、肺炎克雷伯菌和副流感嗜血杆菌为主。氧氟沙星和左氧氟沙星对婴幼儿泪囊炎病原菌均具有较好的体外抗菌活性。

The investigate analysis of 208 cases babies with dacryocystitis pathogens and resistance

Objective To observe the distribution and drug resistance of infantile dacryocystitis pathogens,the foundation were provided for clinical rational drug use.Methods The pathogens separated and cultured were collected from secretions specimen of infantile dacryocystitis patients by conventional methods.Drug sensitivity test was conducted by the disk diffusion method（K-B method）.Results Isolated from a total of 208 non-repeating pathogens,105 grand negative bacilli,accounting for 50.5%（105 /208） ;Grand positive cocci 100,accounting for 48.1%（100 /208） ;Three fungi,accounting for 1.4%（3 /208）.The streptococcus pneumoniae which were firstly separated accounting for 17.3%（36 /208）,followed by staphylococcus epidermidis accounted for 13.0%（27 /208）,klebsiella pneumoniae accounted for 10.6%（22 /208） and deputy haemophilus influenzae accounted for 9.6%（20 /208）.The resistant rates of four main pathogen about ofloxacin and levofloxacin were all 30%.Conclusion Streptococcus pneumoniae,staphylococcus epidermidis,klebsiella pneumoniae and haemophilus parainfluenzae were the primary infantile dacryocystitis pathogens,for which ofloxacin and levofloxacin has better antimicrobial activity in vitro.