| 微囊化异种嗅鞘细胞移植联合中药修复大鼠脊髓损伤 |
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| 引用本文： | 朱文侠,王航辉,韩振奎. 微囊化异种嗅鞘细胞移植联合中药修复大鼠脊髓损伤[J]. 神经解剖学杂志, 2011, 27(6): 681-684 |
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| 作者姓名： | 朱文侠 王航辉 韩振奎 |
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| 作者单位： | 1. 延安大学医学院,延安,716000
2. 上海交通大学医学院,上海,200025 |
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| 基金项目： | 陕西省自然科学基金(08JK502); 延安市科技计划项目(2009KS-22) |
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| 摘 要： | 目的:旨在探讨基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)在异种嗅鞘细胞移植联合中药干预下脊髓损伤中的作用。方法:将188只SD大鼠随机分为正常对照组、单纯损伤组、异种嗅鞘细胞移植组、异种嗅鞘细胞移植联合中药治疗组,损伤组又设1、3、7、14、28 d 5个时相点,免疫组织化学技术检测MMP-9的表达,同时电镜观察血脊髓屏障的变化。结果:脊髓损伤后血脊髓屏障的超微结构不同程度损害、MMP-9表达上调,经干预治疗后出现一定程度的恢复,MMP-9表达下调。结论:脊髓损伤后MMP-9表达水平增加与伤后血脊髓屏障损害的发生、发展密切相关,MMP-9在脊髓损伤后血脊髓屏障损害的病理生理过程中起重要作用。异种嗅鞘细胞移植联合中药对脊髓损伤有较好的修复作用。
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| 关 键 词： | 脊髓损伤 异种移植 嗅鞘细胞 基质金属蛋白酶-9 中药 |
Study on repair of spinal cord injury of rats by heterotransplantation of microencapsulated ensheathing cells combined with China herb |
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| Zhu Wenxia , Wang Hanghui , Han Zhenkui. Study on repair of spinal cord injury of rats by heterotransplantation of microencapsulated ensheathing cells combined with China herb[J]. Chinese Journal of Neuroanatomy, 2011, 27(6): 681-684 |
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| Authors: | Zhu Wenxia Wang Hanghui Han Zhenkui |
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| Affiliation: | Zhu Wenxia1,Wang Hanghui2,Han Zhenkui1 (1.Medical College of Yan'an University,Yan'an 716000,2.Shanghai Jiao Tong University School of Medcine,Shanghai 200025,China) |
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| Abstract: | Objective: To explore the function of(matrix metalloproteinase-9,MMP-9) in heterotransplantation of olfactory ensheathing cells combined with China herb intervention after spinal cord injury.Methods: Healthy 188 SD rats were divided into three groups as following: normal,injury control,transplantation of olfactory ensheathing cells,transplantation of olfactory ensheathing cells combined with China herb.Posttraumatic tissues were achieved at 1,3,7,14 and 28 d after spinal cord injury.The expression of MMP-9 ... |
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| Keywords: | spinal cord injury heterotransplantation olfactory ensheating cells matrix metalloproteinase-9 China herb |
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