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| 大鼠短暂性局灶性脑缺血早期HMGB1在半暗带区的表达 | |
| 引用本文： | 王鄂友,朱正华,朱萧玲,夏中元,熊利泽. 大鼠短暂性局灶性脑缺血早期HMGB1在半暗带区的表达[J]. 神经解剖学杂志, 2011, 27(4): 438-442 |
| 作者姓名： | 王鄂友 朱正华 朱萧玲 夏中元 熊利泽 |
| 作者单位： | 1. 武汉大学人民医院麻醉科,武汉,430060 2. 第四军医大学西京医院麻醉科,西安,710032 |
| 摘 要： | 目的:探讨调节炎症反应的细胞因子HMGB1在脑缺血/再灌注损伤中的时程变化特点。方法:采用大鼠MCAO模型,利用ELISA及免疫组织化学染色方法观察缺血/再灌注后不同时间点脑内HMGB1蛋白的表达变化。结果:ELISA检测提示再灌注后大鼠缺血侧大脑HMGB1表达显著增高,在10 h和70 h形成两次高峰(P<0.05);免疫组织化学染色提示再灌注1 h后部分大鼠(1/5)和再灌注后4,10,22和70 h后全部大鼠梗死区周边半暗带区的细胞外间隙有HMGB1阳性染色颗粒,后期并在部分细胞内出现HMGB1高表达。结论:结果提示,HMGB1不仅与脑缺血/再灌注的晚期损伤有关,亦可能参与了早期损伤过程。 |
| 关 键 词： | 高迁移率族蛋白B1 脑缺血 细胞因子 炎症 半暗带 大鼠 |
Early accumulation of high-mobility group box 1 protein in penumbra region of the brain following transient middle cerebral arterial occlusion in the rat |
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| Wang Eyou,Zhu Zhenghua,Zhu Xiaoling,Xia Zhongyuan,Xiong Lize. Early accumulation of high-mobility group box 1 protein in penumbra region of the brain following transient middle cerebral arterial occlusion in the rat[J]. Chinese Journal of Neuroanatomy, 2011, 27(4): 438-442 | |
| Authors: | Wang Eyou Zhu Zhenghua Zhu Xiaoling Xia Zhongyuan Xiong Lize |
| Affiliation: | Wang Eyou1,Zhu Zhenghua2,Zhu Xiaoling2,Xia Zhongyuan1,Xiong Lize2(1.Department of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan 430060,2.Department of Anesthesiology,Xijing Hospital,the Fourth Military Medical University,Xi'an 710032,China) |
| Abstract: | Objective: To explore the time-course of the expression of High-mobility group box 1(HMGB1) protein which have recently been identified as a late cytokine mediator of sepsis and inflammation in the brain following ischemia-reperfusion injury.Methods: The appearance and location of HMGB1 protein in rat brain following transient cerebral ischemia by the middle cerebral artery occlusion with silicon-coated thread for 2 h was investigated by ELISA and immunohistochemical staining.Results: The expression of HMGB... |
| Keywords: | HMGB1 brain ischemia cytokine inflammation penumbra rat |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |