| 紫锥菊中菊苣酸的提取工艺和含量测定 |
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| 引用本文： | 钟英杰,李亮,徐福亮.紫锥菊中菊苣酸的提取工艺和含量测定[J].中国实验方剂学杂志,2010,16(4):1-4. |
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| 作者姓名： | 钟英杰 李亮 徐福亮 |
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| 作者单位： | 青岛康地恩药业有限公司,山东,青岛,266111 |
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| 摘 要： | 目的:优选紫锥菊药材地上部分的提取工艺,建立菊苣酸的含量测定方法。方法:择L9(34)正交表安排试验,以有效成分菊苣酸的含量为指标优选工艺参数。结果:紫锥菊的最佳提取工艺为12倍量60%乙醇提取3次,每次1.5 h。菊苣酸线性范围在0.011～1.100 mg,r=0.999 8,平均回收率99.51%(RSD=1.01%,n=6)。结论:工艺稳定、可行,适合工业化生产;含量测定方法简便准确,重复性好,可用于控制紫锥菊的质量。
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| 关 键 词： | 紫锥菊 菊苣酸 提取工艺 高效液相色谱法 |
| 收稿时间： | 2009/8/18 0:00:00 |
Studies on extraction process of cichoric acid in Echinacea purpurea |
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| ZHONG Ying-jie,LI Liang and XU Fu-liang.Studies on extraction process of cichoric acid in Echinacea purpurea[J].China Journal of Experimental Traditional Medical Formulae,2010,16(4):1-4. |
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| Authors: | ZHONG Ying-jie LI Liang and XU Fu-liang |
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| Institution: | Qingdao Kangdien Pharmaceutical Co.,Ltd,Qingdao 266111,China;Qingdao Kangdien Pharmaceutical Co.,Ltd,Qingdao 266111,China;Qingdao Kangdien Pharmaceutical Co.,Ltd,Qingdao 266111,China |
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| Abstract: | Objective: To establish the optimal extraction technology and to determine the quantity of cichoric acid from Echinacea purpurea. Method: Nine experiments were carried out through L9(34) orthogonal design. The contents of cichoric acid were determined by HPLC. Result: The best extraction condition obtained was 12 times amount 60% alcohol and extracted for 3 times, 1.5 hours each time. Cichoric acid was linear within the range of 0.011~1.100 mg, r =0.999 8. The average recovery is 99.51%(RSD=1.01%,n=6). Conclusion : This optimal technology is stable and workable, can be used in industrial production. The determination method is suitable for quality control. |
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| Keywords: | Echinacea purpurea cichoric acid Extraction technology HPLC |
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