25例新疆维吾尔族IgA肾病与HLA—DR4、DR12相关性研究 |
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引用本文: | 刘伟莉,陆晨,岳华,朱开春.25例新疆维吾尔族IgA肾病与HLA—DR4、DR12相关性研究[J].中国临床实用医学,2009,3(1):7-9. |
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作者姓名: | 刘伟莉 陆晨 岳华 朱开春 |
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作者单位: | 1. 新疆医科大学研究生院,830054 2. 新疆自治区人民医院肾病科 |
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摘 要: | 目的研究人类白细胞Ⅱ类抗原(HLA—DR4、DR12)与新疆维吾尔族IgA肾病的相关性。方法采用聚合酶链反应-序列特异性引物法(PCR-SSP)对25例新疆维吾尔族IgA肾病及50例正常对照组的HLA-DR4、DR12基因频率进行检测。结果①新疆维吾尔族IgA肾病组的HLA—DR4基因频率高于对照组(P〈0.01);②新疆维吾尔族HLA—DR12基因频率IgA肾病组较正常对照组无明显差异;③新疆维吾尔族HLA-DR4、DR12基因阳性IgA肾病患者的临床表现及病理预后指标与新疆维吾尔族HLA-DR4、DR12基因阴性者比较无明显差异。结论HLA-DR4基因可能是新疆维吾尔族IgAN的易感基因。
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关 键 词: | ISA肾病 HLA-DR4 DR12基因 聚合酶链反应-序列特异性引物法 |
Relationship of hla-dr gene and IgA nephropathy in Xinjiang Uygur population |
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Institution: | LIU Wei-li, LU Chen, YUE Hua ,et al.( Xinjiang Medical University,Institute of Graduate Students, Urumqi 830054, China) |
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Abstract: | Objective To study relationship between of HLA Ⅱ ( HLA-DR4, DR12) and Xinjiang Uygur IgA nephropathy. Methods HLA-DR4 and HLA-DR12 genes in 25 cases of IgA neph ropathy pat-ients and 50 normal controls were investigated by Polymerse Chain Reaction-Sequence Specific Primers (PCR-SSP)technique. Results ①The frequency of HLA-DR4 gene in IgA nephropathy patients was higher than that in normal controls(P 〈0. 01 ) ;②Xinjiang Uygur HLA-DR12 gene frequency of IgA nephropathy group is no difference of the control group ;③The clinical manifestation and pathologic features have no difference between HLA-DR4, DR12 positive and negative IgAN patients. Conclusion HLA-DR4 gene may be susceptible allele in patients with IgA neperopathy in Xinjiang Uygur population. |
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Keywords: | IgA nephropathy HLA-DR4、DR12 gene Polymerse Chain React ion-Sequence SpecificPrimers ( PCR -SSP) |
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