Successful fludarabine‐based hematopoietic stem cell transplantation in a pediatric patient with idiopathic CD4+ lymphocytopenia |
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| Authors: | Amir Ali Hamidieh Zahra Pourpak Amir Hamdi Mohammad Nabavi Ardeshir Ghavamzadeh |
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| Affiliation: | 1. Hematology‐Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, , Tehran, Iran;2. Immunology, Asthma & Allergy Research Institute, Tehran University of Medical Sciences, , Tehran, Iran;3. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, , Houston, TX, USA;4. Rasoul Akram Hospital, Tehran University of Medical Sciences, , Tehran, Iran |
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| Abstract: | Idiopathic CD4+ lymphocytopenia (ICL) is a rare immunodeficiency disease with severe CD4 T‐cell depletion, leading to serious opportunistic infections. The optimal treatment of ICL has not been determined, especially in severe form of the disease. Here, we report an eight‐yr‐old girl with ICL who was successfully treated with fludarabine‐based conditioning HSCT. To the best of our knowledge, this is the first pediatric ICL case that was treated by HSCT. Allogeneic HSCT with a reduced intensity condition (RIC) regimen may be a feasible and curative treatment option in ICL patients with recurrent life‐threatening complications. |
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| Keywords: | idiopathic CD4+ lymphocytopenia hematopoietic stem cell transplantation fludarabine‐based conditioning |
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