Carbapenem-resistant <Emphasis Type="Italic">Enterobacteriaceae</Emphasis> in pediatric bloodstream infections in rural Southern India期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Carbapenem-resistant Enterobacteriaceae in pediatric bloodstream infections in rural Southern India

Authors:	Ramalingam Sekar Manoharan Mythreyee Seetharaman Srivani Dharmaraj Sivakumaran Sivathanu Lallitha Selvam Saranya

Affiliation:	1.Department of Microbiology, Government Theni Medical College,The Tamilnadu Dr MGR Medical University,Theni,India;2.Department of Pediatrics, Government Theni Medical College,The Tamilnadu Dr MGR Medical University,Theni,India;3.Department of Microbiology, Dr ALM Post Graduate Institute of Basic Medical Sciences,University of Madras,Chennai,India

Abstract:	Objective To measure the frequency of antimicrobial resistance in pediatric blood culture isolates of Escherichia coli and Klebsiella spp. with focus on carbapenem resistance. Methods Over a period of three years, pediatric blood culture isolates were tested for antimicrobial susceptibility, including molecular investigations for carbapenem resistance. Results Amikacin, carbapenems, colistin and tigecycline had an antimicrobial efficacy of >70% (n=140). 7 of the 15 randomly selected isolates were positive for carbapenemase gene; among them, five were New Delhi Metallo β-lactamase (NDM). Conclusion There was a high prevalence of Klebsiella spp. in pediatric bacteremia and dissemination of NDMmediated carbapenem resistance in pediatric wards.

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