老年2型糖尿病患者周围神经病变的影响因素

目的探讨老年2型糖尿病患者周围神经病变的影响因素。方法回顾分析1 069例≥60岁的2型糖尿病患者资料,根据肌电图分为糖尿病周围神经病变(DPN)组和非糖尿病周围神经病变(NDPN)组,对两组数据比较,探寻DPN的影响因素。结果①DPN组873例(81.7%),NDPN组196例(18.3%);②DPN与NDPN两组的年龄分别为(71.20±6.70)岁、(69.54±5.92)岁,糖尿病病程分别为(12.42±8.02)年、(9.89±7.67)年,糖化血红蛋白(HbA1c)分别为(9.04±2.52)%、(8.26±1.91)%,性别比(男/女)分别为450/423、83/113,空腹C肽分别为(471.25±320.31)pmol/L、(529.72±298.10)pmol/L,总胆固醇(TC)分别为(4.93±1.27)mmol/L、(4.62±1.09)mmol/L,低密度脂蛋白胆固醇(LDL)分别为(2.95±0.90)mmol/L、(2.77±0.81)mmol/L,以上各指标差异有统计学意义(P<0.05或P<0.01);③Logistic回归结果显示,DPN与年龄、糖尿病病程、HbA1c、TC有关(OR值分别是1.047、1.042、1.152、1.275)。结论 DPN与老年2型糖尿病患者年龄、糖尿病病程、HbA1c、TC相关,联合控制血糖和血脂对于老年人周围神经病变的防治具有重要意义。

Factors influencing diabetic peripheral neuropathy in elderly type 2 diabetic patients

Objective To analyze factors influencing diabetic peripheral neuropathy(DPN) in elderly type 2 diabetic patients.Methods The data of 1 069 patients more than 60 years old who were hospitalized in Beijing Hospital from 2003 to 2010 were retrospectively analyzed.The patients were divided into the DPN group and the non-diabetic peripheral neuropathy(NDPN) group according to electromyography.The clinical characteristics were compared and the influencing factors were analyzed.Results ① There were 873 patients(81.7%)in the DPN group and 196 patients(18.3%)in the NDPN group;② There were significant differences between the DPN group and NDPN group in the following indicators(P<0.01 or P<0.05): age(71.20±6.70) years vs(69.54±5.92) years,duration of diabetes(12.42±8.02) years vs(9.89±7.67) years,glycosylated hemoglobin(HbA1c)(9.04±2.52)% vs(8.26±1.91)%,sex ratio(male/female) 450/423 vs 83/113,fasting C peptide(471.25±320.31)pmol/L vs(529.72±298.10)pmol/L,total cholesterol(TC)(4.93±1.27)mmol/L vs(4.62±1.09)mmol/L,and low density lipoproteincholesterol(LDL)(2.95±0.90) mmol/L vs(2.77±0.81)mmol/L.③ Logistic regression analysis showed that ORs of age,duration of diabetes,HbA1c and TC were 1.047,1.042,1.152,and 1.275 respectively.Conclusions In elderly type 2 diabetic patients,age,duration of diabetes,HbA1c and TC were found to be the influencing factors of DPN.It seems to be beneficial to control both blood glucose and blood lipid to prevent and treat DPN in elderly type 2 diabetic patients.