东北鹤虱果实中抗菌活性成分的研究

自紫草科植物东北鹤虱Lappula echinata Gilib.果实中分离出十六种化合物。其中晶ⅩⅢ(—)—绿花倒提壶酸((—)-viridifloric acid)为一新的天然产物,晶ⅩⅥ为一新酯甙,对香豆酰-α-L-鼠李吡喃糖甙[1-(p-coumaroyl)-α-L-rhamnopyranose]。并鉴定其它八种化合物为棕榈酸Ⅰ、尿囊素Ⅲ、腺嘌呤Ⅳ、腺甙Ⅶ、L-亮氨酸Ⅹ、L-缬氨酸Ⅺ、L-酪氨酸Ⅻ和琥珀酸ⅩⅤ。Ⅰ、Ⅵ、ⅩⅢ、ⅩⅤ和ⅩⅥ显示了不同程度的抗菌活性。

STUDIES ON THE ANTIBACTERIAL CONSTITUENTS IN THE FRUIT OF LAPPULA ECHINATA GILIB

Sixteen constituents (Ⅰ～ⅩⅥ) were isolated from the fruit of Lappula echinata Gilib.. Eight of them were identified as palmitic acid(Ⅰ), allantoin (Ⅲ), adenine(Ⅵ), adenosine(Ⅶ), L-leucine(Ⅹ), L-valine(Ⅺ), L-tyrosine(Ⅻ), and succinic acid(ⅩⅤ).(-)-Viridifloric acid (ⅩⅢ) was found from natural resource for the first time. All of them were first reported to occur in the Lappula genus. A new compound, 1-(p-coumaroyl)-α-L-rhamnopyranose(ⅩⅥ), was elucidated on the basis of spectral data and chemical evidence. Antibacterial experiment showed that compounds Ⅰ, Ⅵ, ⅩⅢ, ⅩⅤ and ⅩⅥ were all active. Structure determination of the other compounds is still underway.