异戊二烯与精神分裂症的相关性研究

目的研究精神分裂症呼出气体中异戊二烯浓度与症状的相关性。方法以住院精神分裂症为研究对象,用气相色谱-质谱联用仪捡测其呼出气体中异戊二烯的浓度,同时用阳性与阴性症状量表（PANSS）对精神分裂症的症状进行评定。结果精神分裂症患者呼出气体中异戊二烯浓度与阳性症状正相关（r=0．705,P〈0．01）。在抗精神病药物治疗3周后,异戊二烯浓度明显下降（P〈0．05）。结论精神分裂症呼出的异戊二烯浓度与阳性症状相关,随阳性症状的加重．有增多的趋势。抗精神病药物对其有明显的抑制效应。

Correlation Study on Isoprene Breath Levels and Schizophrenia.

Objective To survey the correlation between schizophrenia and exhaled levels of isoprene. Methods The subjects were inpatients with schizophrenia. Isoprene breath levels were measured by gas chromatography combined with mass spectroscopy （GC--MS）. The schizophrenia was scored by the positive and negative symptom scale （PANSS）. Results The concentrations of isoprene exhaled by the patients with schizophrenia were correlated with the positive symptoms （r= 0. 705,P〈0.01 ）. After three weeks of treatment with antipsychotic drugs, the concentrations of isoprene exhaled by the patients with schizophrenia significantly decreased （P〈50.05）. Conclusion For the patients with schizophrenia, the concentrations of isoprene in tbe breath were positive correiated with positive symptoms, and could be inhibited by antipsychotie drugs.