大鼠血管性痴呆模型制作

目的：制作大鼠血管性痴呆（VD）模型，方法：2－VO法（双侧颈总动脉永久性结扎），对30只Wistar大鼠进行处理，通过Morris迷宫实验检测其定位航行和空间探索行为功能，判断实验组模型学习记忆和空间记忆的认知能力，并与正常对照组进行对比。结果：实验组与正常对照组定位航行实验和空间探索实验均有十分显著差异（P＜0．01）。痴呆率为83％，轻度痴呆占40％，中度痴呆占56％和重度痴呆占4％。结论：2－VO法制作的血管性痴呆模型具有制作简单，成功主高，重复性好，痴呆症状稳定等优点，可以作为血管性痴呆模型用于基础实验研究。

Establishing vascular dementia model in rats

Objective: Our purpose was to establish vascular dementia (VD) model in rats. Methods: Thirty Wistar rats in experimental group were treated with a permanent bilateral occlusion of both common carotid arteries (2-VO) to establish vascular dementia model. These models were checked by using Morris maze for behavior ability of learning and memory and intelligence, and compared with control group. Results: Wistar rats in experimental group presented a significant difference with control group ( P <0.01). The rate of dementia was 83%, and the percentage of light, middle, and severe of dementia degrees were 40%, 56%, and 4%, respectively. Conclusion: This model of vascular dementia is useful for studying vascular dementia. It has the practicability and reliability and can be used in basic experiment studying.