Treatment of imported cases of falciparum malaria in France with halofantrine |
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| Authors: | J P Coulaud J Le Bras S Matheron B Moriniere A G Saimot J F Rossignol |
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| Affiliation: | 1. Institut de Médecine et d''Epidemiologie Tropicales and Department of Tropical Medicine, Hôpital Claude Bernard, 75944 Paris Cédex 19, France;2. Dept. of Internal Medicine, University of South Alabama, School of Medicine, Mobile, Alabama, USA;1. Department of Veterinary and Biomedical Science, The Pennsylvania State University, 321 Huck Life Sciences, University Park, PA, 16802, USA;2. Department of Ecosystem Science and Management, The Pennsylvania State University, 210 Forest Resources Building, University Park, PA, 16802, USA;3. Department of Ecosystem Science and Management, The Pennsylvania State University, 303 Forest Resources Building, University Park, PA, 16802, USA;4. Department of Ecosystem Science and Management, The Pennsylvania State University, 101 Forest Resources Building, University Park, PA, 16802, USA;5. Department of Food Science, The Pennsylvania State University, 332 Rodney A Erickson Food Science Building, University Park, PA, 16802, USA;6. Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, 16802, USA;1. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;2. Persian Gulf Marine Biotechnology Research Center, Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran;3. Chemistry Department, Shiraz University, Shiraz, Iran;1. Department of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, U.S. Nagar, 263145, Uttarakhand, India;2. Department of Biological Sciences, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, U.S. Nagar, 263145, Uttarakhand, India |
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| Abstract: | ![]()
Halofantrine is a 9-phenanthrenemethanol which is effective against multi-drug resistant strains of Plasmodium falciparum. It has been shown to be highly effective and extremely well tolerated in the treatment of imported cases of falciparum malaria in France. A total of 1,500 mg administered in three 500 mg doses at six-hour intervals results in a 100% cure rate in semi-immune subjects. This dosage should be repeated after 14 days to obtain the same cure rate in non-immune patients. Minor clinical side effects included epigastric pains, nausea and, in one case, a skin rash. |
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