| Expression of p63 and Cyclooxygenase-2 and Their Correlation in Skin Tumors |
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| 引用本文： | 吴艳,刘厚君,李家文. Expression of p63 and Cyclooxygenase-2 and Their Correlation in Skin Tumors[J]. 华中科技大学学报(医学英德文版), 2007, 27(2): 206-208. DOI: 10.1007/s11596-007-0227-6 |
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| 作者姓名： | 吴艳 刘厚君 李家文 |
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| 作者单位： | Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430030 China，Wuhan 430030 China，Wuhan 430030 China |
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| 摘 要： | To study the expression of p63 and cyclooxygenase-2 (cox-2) in skin tumors and evalu- ate the correlation between p63 and cox-2, the expressions of cox-2 and p63 were measured by streptavidin-peroxidase complex immunohistochemical technique in 17 cases of skin squamous cell carcinoma(SCC), 19 cases of Bowen's disease(Bowen), 11 cases of actinic keratosis(AK), 12 cases of seborreic keratosis(SK) and 13 specimens of normal skin. Our results showed that the expression of p63 in skin squamous cell carcinoma, Bowen's disease and actinic keratosis were significantly higher than that in seborreic keratosis, while the expression of p63 in seborreic keratosis was sig- nificantly higher than that in normal skin. The expression of cox-2 in skin squamous cell carcinoma, Bowen's disease and actinic keratosis were significantly higher than that in seborreic keratosis, while no statistical difference was noted in the expression of cox-2 between seborreic keratosis and normal skin. Cox-2 expression was positively correlated with the high p63 expression in malignant skin tu- mors. The increased expression of cox-2 and p63 may play an important role in the development of skin tumors and work synergetically in malignant skin tumors.
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| 关 键 词： | 皮肤肿瘤 p63基因 环加氧酶-2 基因表达 相关性 |
| 收稿时间： | 2006-09-23 |
Expression of p63 and cyclooxygenase-2 and their correlation in skin tumors |
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| Wu Yan,Liu Houjun,Li Jiawen. Expression of p63 and cyclooxygenase-2 and their correlation in skin tumors[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2007, 27(2): 206-208. DOI: 10.1007/s11596-007-0227-6 |
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| Authors: | Wu Yan Liu Houjun Li Jiawen |
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| Affiliation: | Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | To study the expression of p63 and cyclooxygenase-2 (cox-2) in skin tumors and evalu- ate the correlation between p63 and cox-2, the expressions of cox-2 and p63 were measured by streptavidin-peroxidase complex immunohistochemical technique in 17 cases of skin squamous cell carcinoma(SCC), 19 cases of Bowen's disease(Bowen), 11 cases of actinic keratosis(AK), 12 cases of seborreic keratosis(SK) and 13 specimens of normal skin. Our results showed that the expression of p63 in skin squamous cell carcinoma, Bowen's disease and actinic keratosis were significantly higher than that in seborreic keratosis, while the expression of p63 in seborreic keratosis was sig- nificantly higher than that in normal skin. The expression of cox-2 in skin squamous cell carcinoma, Bowen's disease and actinic keratosis were significantly higher than that in seborreic keratosis, while no statistical difference was noted in the expression of cox-2 between seborreic keratosis and normal skin. Cox-2 expression was positively correlated with the high p63 expression in malignant skin tu- mors. The increased expression of cox-2 and p63 may play an important role in the development of skin tumors and work synergetically in malignant skin tumors. |
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| Keywords: | skin tumors cox-2 p63 |
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