Human infections due to Schizophyllum commune: Case report and review of the literature |
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| Institution: | 1. Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Viale C. Golgi 19, 27100 Pavia, Italy;2. Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, Viale C. Golgi 19, 27100 Pavia, Italy;3. Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Università degli Studi di Pavia, 27100 Pavia, Italy;4. Department of Biomedical Sciences for Health, Università degli Studi di Milano, via Pascal 36, 20133 Milan, Italy;5. Specialization School of Microbiology and Virology, Università degli Studi di Pavia, 27100 Pavia, Italy;1. Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Syowa-Ku, 466-8560 Nagoya, Japan;2. Department of Pulmonary Medicine, National Hospital Organization Higashi Nagoya Hospital, 5-101 Umemorizaka, Meito-Ku, 465-8620 Nagoya, Japan;3. Department of Quality Control, Matsuurayakugyo Co., Ltd., 24-21 Enjo-Chou, Syowa-Ku, 466-0054 Nagoya, Japan;4. Department of Microbiology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku-Ku, 468-8503 Nagoya, Japan;1. Department of Laboratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan;2. Department of Orthopedic Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan;1. Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India;2. Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India;1. Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok 10700, Thailand;2. Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;3. Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;1. Department of Biomedical Science for Health, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy;2. Microbiology and Virology Unit IRCCS Policlinico San Matteo, Pavia, Italy;3. Microbiology Institute, ASST ‘Papa G iovanni XXIII’, Bergamo, Italy;4. Microbiology Laboratory, A.O. Spedali Civili, Brescia, Italy;5. Microbiology - ASST Lariana, Como, Italy;6. Laboratory of Microbiology and Virology, San Raffaele Scientific Institute, Milano, Italy;7. Microbiology Laboratory, Fondazione IRCCS C à Granda O. Maggiore Policlinico, Milano, Italy;8. Microbiology Section, Humanitas Research Hospital, Milano, Italy;9. Microbiology Laboratory, Ospedale San Gerardo, Monza, Italy;10. Medicina di Laboratorio, IRCCS Policlinico San Donato, Milano, Italy;11. Microbiology Unit, ASST Lodi, Italy;12. Microbiology and Virology Unit, ASST Bergamo Ovest Treviglio, Italy;13. Laboratory of Microbiology and Virology, ASST Lecco, Italy |
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| Abstract: | Schizophyllum commune is an environmental basidiomycetous fungus, causing occasional, predominantly respiratory, infections in humans. Although S. commune is considered an emerging pathogen, some authors pointed out the possibility that the increase in the diagnosed cases may be also due to recent advances in diagnostic technologies now allowing a more prompt and precise identification at the species level. Here we describe the first Italian case of chronic non-invasive fungal rhinosinusitis due to S. commune in an immunocompetent subject and update the literature review on S. commune sinusitis published between 2012–2019. A timely diagnosis is important to avoid local and systemic complications due to infection with this fungus. In our case, prompt identification at species level was only possible with the use of MALDI-TOF mass spectrometry and confirmed by sequence analysis of ribosomal DNA ITS regions, due to the difficulty in achieving a correct and rapid identification using routine morphological analysis. |
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| Keywords: | Fungal rhinosinusitis Fungus ball DNA sequencing MALDI-TOF MS Fiberoptic endoscopic sinus surgery (FESS) |
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