The antinociceptive effect of intrathecal tramadol in rats: the role of alpha 2-adrenoceptors in the spinal cord |
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| Authors: | Cai Li Shu-Qin Chen Bing-Xue Chen Wen-Qi Huang Ke-Xuan Liu |
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| Affiliation: | (1) Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan 2nd road, 510080 Guangzhou, China;(2) Department of Gynecology and Obstetrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; |
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| Abstract: | ![]()
Purposes The alpha 2 (α2)-adrenoceptor is highly important in the antinociception of tramadol administered systemically and intrathecally. However, it is unclear whether tramadol at the spinal level exerts an antinociceptive effect by directly binding with α2-adrenoceptors in the spinal cord. This study was conducted to investigate the relationship between α2-adrenoceptors and the antinociception of tramadol at the spinal level. |
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