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Characteristics of the macula in amblyopic eyes by optical coherence tomography
Authors:Xin-Mei Wang  Dong-Mei Cui  Ling Zhen  Xiao Yang  Li-Jun Huo  Xing Liu  Jun-Wen Zeng
Affiliation:State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, Guangzhou 510060, Guangdong Province, China;Department of Ophthalmology, the Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, Guangzhou 510060, Guangdong Province, China;Department of Ophthalmology, the Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, Guangzhou 510060, Guangdong Province, China;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, Guangzhou 510060, Guangdong Province, China;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, Guangzhou 510060, Guangdong Province, China;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, SunYat-sen University, Guangzhou 510060, Guangdong Province, China
Abstract:
AIM: To test the hypothesis that amblyopic neuroretina may have an altered thickness when compared to the normal.METHODS: Twenty-five amblyopic, young patients between the ages of 7 and 11 years old were studied. The interested neuroretina areas are defined into 10 sub-regions according to superior-inferior, nasal-temoral, and peri-para axis, which cross the fovela structure. The thicknesses of ten, defined macular regions were separately measured by optical coherence tomography (OCT) and analyzed by t-test. RESULTS: The average thickness of neuroretina in the exact foveola of the amblyopic eyes is larger than that of normal eyes (P<0.05), but the other nine regions have no significant difference. Interestingly, in both the normal and amblyopic eyes, the temporal area looks thinner than other quadrants (P<0.05). CONCLUSION: Thickness alteration may be associated with amblyopic disorders in young patients. Studying a larger volume of subjects of similar age is required to confirm this observation.
Keywords:amblyopia   macula flava   optical coherence tomography
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