| 落新妇苷固体分散体在大鼠体内的药动学研究 |
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| 引用本文： | 胡凯,扈荣,许鹏庆,白海波,傅旭春. 落新妇苷固体分散体在大鼠体内的药动学研究[J]. 中国现代应用药学, 2013, 30(10): 1102-1104 |
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| 作者姓名： | 胡凯 扈荣 许鹏庆 白海波 傅旭春 |
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| 作者单位： | 浙江大学药学院,杭州华东医药集团生物工程研究所有限公司,杭州华东医药集团生物工程研究所有限公司,杭州华东医药集团生物工程研究所有限公司,浙江大学城市学院药物研究所 |
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| 摘 要： | 目的 研究大鼠口服落新妇苷固体分散体后的药物动力学参数。方法 采用HPLC法测定大鼠口服落新妇苷固体分散体后血浆中的落新妇苷血药浓度。用kinetica软件计算动力学参数。结果 落新妇苷在大鼠体内的药物动力学过程符合二室模型。AUC0-480min为1.98±0.60 mmol?min?L-1。结论 将落新妇苷制成固体分散体可以显著提高其生物利用度。
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| 关 键 词： | 落新妇苷 固体分散体 药物动力学 生物利用度 |
| 收稿时间： | 2013-03-04 |
| 修稿时间： | 2013-06-08 |
Study on Pharmacokinetics of Astilbin Solid Dispersion in Rat |
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| HU Kai,HU Rong,XU Pengqing,BAI Haibo and FU Xuchun. Study on Pharmacokinetics of Astilbin Solid Dispersion in Rat[J]. The Chinese Journal of Modern Applied Pharmacy, 2013, 30(10): 1102-1104 |
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| Authors: | HU Kai HU Rong XU Pengqing BAI Haibo FU Xuchun |
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| Affiliation: | College of Pharmaceutical Sciences, Zhejiang University,Hangzhou Huadong Medicine Group Biotechnology R,Hangzhou Huadong Medicine Group Biotechnology R,Hangzhou Huadong Medicine Group Biotechnology R,Institute of Materia Medica, Zhejiang University City College |
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| Abstract: | Objective To study the pharmacokinetics of astilbin solid dispersion in rat. Methods RP-HPLC has been used to determine the astilbin concentration in the plasma of rats. The pharmacokinetic parameters were calculated with Kinetica program. Results After the rats were orally adminstered with astilbin solide dispersions, the pharmacokinetic process of astilbin in rats was found to be consistent with the two-compartment model. The AUC0-480min was 1.98±0.60 mmol?min?L-1. Conclusion The astilbin in solid dispersion can greatly improve its bioavailability in rat. |
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| Keywords: | astilbin solid dispersion pharmacokinetics bioavailability |
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