复方倍他米松联合山莨菪碱注射治疗眉毛斑秃的临床观察

目的 观察复方倍他米松联合山莨菪碱注射治疗眉毛斑秃的疗效、安全性及患者满意度。方法 66例患者随机分为复方倍他米松组（A组）和复方倍他米松联合山莨菪碱组（B组），两组均按0．2ml／cm^2标准，从眉毛中央向两侧注射，每1个月注射1次，并观察疗效，3个月后根据不良事件发生率和患者的主观感受分析其安全性和满意度。结果 A组在治疗后1、2、3个月的有效率分别为31．25％、53．13％和71．88％，B组的有效率分别为58．82％、73．53％和88．23％，B组的疗效明显优于A组（P〈0．05）；疗程结束后B组的不良事件发生率与A组相似（P〉0．05）；B组的患者满意率为97．06％，高于A组的78．13％（P〈0．05）。结论 复方倍他米松注射液联合山莨菪碱注射液治疗眉毛斑秃较单独采用复方倍他米松可获得更好的疗效和满意度。

Clinical evaluation of compound betamethasone combined with anisodamine in treatment of eyebrow alopecia areata

Objective To observe the curative effect, safety and patient's satisfaction degree of combining compound betamethasone with anisodamine injection in the blocking treatment of eyebrow alopecia areata.Methods A total of 66 cases were randomly divined into two groups: patients were treated by compound betamethasone ( group A) and combining compound betamethasone with anisodamine ( group B). The drugs were injected from the middle of eyebrow alopecia areata to two sides by the standard of 0. 2 ml/cm2 in both groups one time a month. The curative effect of the all cases were observed at 1, 2 and 3 months after treatment. The safety of them were evaluated based on incidence rate of the side effect and their satisfactory degree were evaluated based on subjective reception 3 months after treatment. Results The effective rates in the group B were 58.82 %, 73.53 % and 88.23 % by turns at 1,2 and 3 months after treatment, and those in the group A were 31.25 %, 53.13 % and 71.88 %, respectively. The curative effect in the group B was better than that in the group A (P ＜ 0. 05), and the incidence rate of side effect in the group B was similar to that in the group A (P＞0.05) and the patient's satisfaction degree in group B was better than that in group A (P ＜0. 05) 3months after treatment. Conclusion The compound betamethasone combined with anisodamine injection in the treatment of eyebrow alopecia areata has superior curative efficacy, more safety and higher satisfactory degree in the patients.