三维适形放疗同步替吉奥化疗治疗术后复发直肠癌的疗效观察

目的 观察三维适形放疗同步替吉奥化疗治疗术后复发直肠癌的近期疗效和毒副反应.方法 40例直肠癌术后复发患者,应用三维适形放疗(1.8～2.0 Gy/次,5次/周,总剂量54～65Gy)同步口服替吉奥胶囊化疔(40 mg/m2,2次/d,口服,连服28 d,42 d为1个周期,放疗结束后继续化疗2个周期).结果 全组患者均完成治疗,依从性好.总有效率为70.0%,症状改善率为90.0%.1年生存率为70.0%,1年局部控制率为62.5%.主要毒副反应为消化道反应、血液学毒性、放射性皮肤反应,多为1、2级,仅见1例3级腹泻.结论 三维适形放疗同步替吉奥化疗治疗直肠癌术后复发的疗效确切,毒副反应可耐受,能明显改善患者的生活质量.

Abstract：

Objective To observe the local control rate, survival time and side effect of threedimensional eonformal radiation therapy combined with Tegafur for postoperative recurrent rectal carcinoma.Methods Forty patients with postoperative recurrent rectal carcinoma received three-dimensional conformal radiation therapy, 1.8-2.0 Gy/once, 5 times every week and the total dose was 54-65 Gy.At the same time, the patients took Tegafur orally 40 mg/m2 twice per day for consecutive 28 days, and one cycle lasted for 42 days.The chemotherapy was applied for 2 cycles after radiotherapy.Results The total effective rate ( CR + PR) was 70.0%, improvement rate was 90.0%, 1-year survival rate was 70.0%, and 1-year local control rate was 62.5%.There was only a little side effect.Conclusions Three-dimensional conformal radiation therapy combired with Tegafur for postoperative recurrent rectal carcinoma have definite effect, with a high local control rate, and patients well tolerance the treatment without serious side effect.It can apparently improve the life quality of the patients.

Effecacy of three-dimensional conformal radiation therapy combined with Tegafur for postoperative recurrent rectal carcinoma

Objective To observe the local control rate, survival time and side effect of threedimensional eonformal radiation therapy combined with Tegafur for postoperative recurrent rectal carcinoma.Methods Forty patients with postoperative recurrent rectal carcinoma received three-dimensional conformal radiation therapy, 1.8-2.0 Gy/once, 5 times every week and the total dose was 54-65 Gy.At the same time, the patients took Tegafur orally 40 mg/m2 twice per day for consecutive 28 days, and one cycle lasted for 42 days.The chemotherapy was applied for 2 cycles after radiotherapy.Results The total effective rate ( CR + PR) was 70.0%, improvement rate was 90.0%, 1-year survival rate was 70.0%, and 1-year local control rate was 62.5%.There was only a little side effect.Conclusions Three-dimensional conformal radiation therapy combired with Tegafur for postoperative recurrent rectal carcinoma have definite effect, with a high local control rate, and patients well tolerance the treatment without serious side effect.It can apparently improve the life quality of the patients.