Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation |
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| Authors: | Florian Grabellus Sien-Yi Sheu Boris Schmidt Michael Flasshove Cornelius Kuhnen Steffen Ruchholtz Georg Taeger Kurt Werner Schmid |
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| Affiliation: | (1) Institute of Pathology, University Hospital of Essen, University Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany;(2) Department of Trauma Surgery, University Hospital of Essen, Essen, Germany;(3) Department of Internal Medicine (Cancer Research), University Hospital of Essen, Essen, Germany;(4) Institute of Pathology, University Hospital Bergmannsheil, Bochum, Germany |
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| Abstract: | ![]()
Leiomyosarcomas (LM) of the soft tissue comprise approximately 5–10% of all soft tissue sarcomas. Besides the classic LM, several distinctly uncommon features of the cellular and growth patterns of LM have been described. The term “dedifferentiated LM” has rarely been used in the literature to describe soft tissue LM containing areas of undifferentiated, pleomorphic appearance or detectable heterologous differentiation. We report on a case of high-grade LM with almost entire transition to an osteosarcoma, which was classified as recurrent high-grade LM with heterologous osteosarcomatous differentiation. The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies. |
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| Keywords: | Sarcomas Soft tissue |
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