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| 桑叶黄酮对胰岛素抵抗大鼠氧化应激影响 | |
| 引用本文： | 苏言辉,祝红梅,夏道曼,杨矫,陈秋.桑叶黄酮对胰岛素抵抗大鼠氧化应激影响[J].中国公共卫生,2011,27(10). |
| 作者姓名： | 苏言辉 祝红梅 夏道曼 杨矫 陈秋 |
| 作者单位： | 1. 泸州医学院附属医院内分泌科,四川泸州646000;枣庄市薛城区人民医院内三科 2. 泸州医学院附属医院内分泌科,四川泸州,646000 3. 成都中医药大学附属医院内分泌科 |
| 基金项目： | 四川省重大攻关项目，四川省中管局重点课题 |
| 摘 要： | 目的 观察桑叶黄酮对2型糖尿病胰岛素抵抗大鼠氧化应激作用,并探讨其改善胰岛素抵抗的分子机制.方法高脂饮食饲养成年雄性SD大鼠8周诱导大鼠胰岛素抵抗模型,随机分为糖尿病模型组(MOD组)和桑叶黄酮治疗组(MLF组),对照组为正常SD大鼠(NOR组)；测量各组大鼠空腹血糖(FPG)、胰岛素(FINS)及血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性,计算胰岛素敏感指数(ISI)和胰岛素抵抗指数(IRI).结果 与NOR组比较,MOD组MDA升高,为(8.73±0.85) nmol/L,SOD、GSH-Px活性均降低,分别为(226.45±17.54)、(529.03±69.56)U/mL；与MOD组比较,MLF组能降低病鼠FINS和IRI,分别为(25.83±2.1) mU/L和(8.86±0.96),提高ISI,为(5.08±0.09),降低FPG和MDA含量,分别为(7.95±1.85) mmol/L和(6.82±0.79) nmol/mL,增强SOD活性,为(297.85±22.16) U/mL.结论桑叶黄酮能改善2型糖尿病胰岛素抵抗大鼠高胰岛素血症,降低血糖,提高胰岛素敏感性,降低氧化应激水平,具有抗氧化能力. |
| 关 键 词： | 桑叶黄酮 2型糖尿病 胰岛素抵抗 氧化应激 |
Effect of mulberry flavonoids on oxidatie stress among diabetic rats with insulin resistance |
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| SU Yan-hui,ZHU Hong-mei,XIA Dao-man,et al..Effect of mulberry flavonoids on oxidatie stress among diabetic rats with insulin resistance[J].Chinese Journal of Public Health,2011,27(10). | |
| Authors: | SU Yan-hui ZHU Hong-mei XIA Dao-man |
| Institution: | SU Yan-hui,ZHU Hong-mei,XIA Dao-man,et al.Department of Endocrinology,Luzhou Medical College(Luzhou 646000,China) |
| Abstract: | Objective To observe the effect of mulberry flavone on oxidative stress in type 2 diabetes rats with insulin resistance and to explore molecular mechanism of mulberry flavone against insulin resistance.Methods The adult male SD rats were fed with high-fat diet for 8 weeks,and then randomly divided into model group with type 2 diabetes(MOD group),mulberry leaves flavone treatment group(MLF),and normal control group(NOR group).We observed levels of fasting plasma glucose(FPG),fasting insulin(FINS),serum malon... |
| Keywords: | mulberry flavone type 2 diabetes insulin resistance oxidative stress |
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