慢性海洛因中毒致大鼠睾丸、附睾及精囊组织病理学改变

利用光镜及电镜对大白鼠慢性海洛因中毒模型及对照组的睾丸、附睾及精囊作组织细胞形态学检查。光镜结果表明，海洛因中毒组大鼠睾丸生精管生精上皮细胞层次明显减少，腔内精子稀少，畸形精子及脱落的生精细胞增多；附睾及精囊均存在腔内精子明显减少。电镜结果表明，海洛因中毒组大鼠睾九精子细胞减少，部分精子细胞变性、脱落，精子提前成熟，精子颈段线粒体肿胀，精子减少；支持细胞水肿，个别支持细胞核内水肿，支持细胞内溶酶体明显增多；精原细胞出现核膜扩张；精母细胞停滞于分裂前期；个别问质细胞破坏。附睾管上皮主细胞内溶酶体及吞噬泡明显增多，腔内精子减少，有较多的膜样小体，主细胞静纤毛局部明显减少。研究结果从组织病理学角度，证实了慢性海洛因中毒可导致睾丸生精功能明显障碍。

HISTOPATHOLOGICAL EFFECTS OF CHRONIC INTOXICATION BY HEROINON TESTIS,EPIDIDYMIDES AND SEMINAL VESICLES IN RATS

Tissue sections from testis epididymides and seminal vesicles from 15male rats which were chronically intoxicated by heroin and 15 normal male rats werestudied by light microscope(LM) and transmission electron microscope (TEM). Theresults showed that seminiferous tubules from all the rats intoxicated by herion presented a striking reduction in the thickness of the germinal epithelium and prematuresperm was found in seminiferous tubules from 5 of the normal, 14 of the rats intoxicatedby heroin showed hyposperm, detachment of immature germcells and many teratospermwhich appeared in the seminiferous tubules. Tissue sections from epididymides andseminal vesicles from all the 15 rats intoxicated by herion showed hyposperm of the lumina. TEM studies also showed a striking decrement in spermatid, denaturative spermatid which appeared free in the tubular lumina, swelling and hydropic change in mitochondria in the necks of sperm, hydropic change and a considerable alterations abovewere found in the tissue sections from testis from 4 rats intoxicated by herion. OF the 4rats, 2 rats presented a striking expansion in nuclear envelopes in several spermatogoniaand the vast majority of spermatocytes stagnated in premeiotic period. Individual leydig's cells were found destroyed. TEM studied also showed a striking increase ofphagosomes and pinosomes in the absorbing cells in epididymal epithelium, a partialreduction of microvilli in the absorbing cells in epididymal epithelium, many membraniform bodies and teratosperm in the tubular lumina.These histopathological alterations proved further the toxic effects of heroin sampleson testis and epididymides.