| 用动力学模型定量分析低钠透析液对钠清除量的影响 |
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| 引用本文： | 单亦升,田信奎,汪涛. 用动力学模型定量分析低钠透析液对钠清除量的影响[J]. 中国血液净化, 2005, 4(3): 127-130 |
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| 作者姓名： | 单亦升 田信奎 汪涛 |
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| 作者单位： | 100034,北京,北京大学第一医院肾脏病研究所 |
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| 基金项目： | 中华人民共和国教育部长江学者奖励计划和教育振兴引动计划专项基金 (985工程资助 ) |
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| 摘 要： | 目的 定量地分析低钠透析液对钠清除量的影响以便为临床减少钠潴留的发生提供策略。方法 我们依据三孔模型 ,建立了单次透析过程中钠转运的数学模型 ,描述了低钠透析液对钠清除量的影响。并在合理假设的基础上探讨了低钠透析液中合适的钠浓度。结果 钠浓度每降低 5mmol/L ,清除量增加 0 .2 3g。低钠透析液中合适的钠浓度可能 1 2 8mmol/L。结论 低钠透析液能够明显增加钠的清除。
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| 关 键 词： | 钠潴留 钠清除 低钠透析液 动力学模型 |
| 修稿时间： | 2004-11-17 |
Quantitative description of sodium removal of low - sodium dialysis solution |
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| SHAN Yisheng,TIAN Xinkui,WANG Tao. Quantitative description of sodium removal of low - sodium dialysis solution[J]. Chinese Journal of Blood Purification, 2005, 4(3): 127-130 |
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| Authors: | SHAN Yisheng TIAN Xinkui WANG Tao |
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| Affiliation: | SHAN Yisheng,TIAN Xinkui,WANG Tao. Institute of Nephrology,First Hospital,Peking University,Beijing 100034,China |
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| Abstract: | Objective We quantitatively described the sodium removal with low-sodium dialysis solutions to prevent the development of sodium and fluid retention in peritoneal dialysis patients. Methods Kinetic model of sodium removal during single dwell time was established according to three-pore model, and by which the sodium removal with low-sodium dialysis solutions was analyzed. The appropriate sodium concentration in dialysis solutions was discussed. Results More than 0.23g sodium could be removed with 5 mmol/l of decrease in dialysate sodium concentration. The appropriate sodium concentration in dialysis solution may be about 128 mmol/l. Conclusion Our result demonstrated that low-sodium solution could significantly increase sodium removal. |
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| Keywords: | Sodium retention Sodium removal Low-sodium dialysis solution Kinetic modelling |
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