降压滴丸急性毒性及其药效学研究

目的:研究降压滴丸对高血压的用药安全及其药效。方法:采用急性毒性试验连续观察给降压滴丸后14 d内动物的行为反应。药效学实验采用肾动脉结扎的方法建立大鼠肾性高血压模型,通过空白对照组、模型组、阳性对照组、降压滴丸高剂量组、中剂量组、低剂量组的建立,从而比较观察其降压效果;并通过记录小鼠耳微动脉、微静脉血管管径变化,比较降压滴丸的扩血管作用。结果:降压滴丸急性毒性实验连续观察14 d,未发现动物死亡,体重均有所增长,肉眼观察未见明显毒性反应。药效学实验发现高、中、低3个剂量组均可降低肾性高血压大鼠血压,并能扩张小鼠耳微动脉、微静脉血管。结论:初步证明降压滴丸是安全的并具有一定的降血压作用。

To research the Acute toxicity and Main Pharmacodynamics of Jiangya Dripping pills

Objective To research the safety and potency of Jiangya Dripping pills on hypertension.Method The experiments in acute toxicity were gave by oral administration of Jiangya Dripping pills to mice given more times a day with the Maximum dosage to observe their responses immediately after the administration and continuously for 14 days.Renal hypertension model was established by ligation of the left renal artery.Healthy rats were divided into a Blank control group,a model group,a positive control group,a high dose of Jiangya Dripping pills group,a middle dose of Jiangya Dripping pills group and a low dose of Jiangya Dripping pills group to observe the effect of Jiangya Dripping pills on lowering blood pressure.In addition,the action of vasodilation was observed by microscope to record vessel diameters of arteriolae and veinules in mice’s ears.Result After 14 days continuous observation,no mouse was dead and Their weight increased,no significant toxicity occurred by naked eyes.All the dosages of Jiangya Dripping pills could significantly depress blood pressure of experimental renal hypertension in rats,and expand the arteriolae and veinules in mice’s ears.Conclusion Jiangya Dripping pills can obviously lower blood pressure,and it is preliminary proven to be safe.