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| 大黄素抗肿瘤作用研究进展 | |
| 引用本文： | 林玩福,汪晨,凌昌全. 大黄素抗肿瘤作用研究进展[J]. 中国中药杂志, 2015, 40(20): 3937-3940 |
| 作者姓名： | 林玩福 汪晨 凌昌全 |
| 作者单位： | 第二军医大学长海医院中医系, 上海 200433,第二军医大学长海医院中医系, 上海 200433,第二军医大学长海医院中医系, 上海 200433 |
| 基金项目： | 国家自然科学基金项目(30901986);全国优秀博士学位论文作者专项(201366) |
| 摘 要： | 大黄素是大黄的主要有效成分之一,具有消炎、抑菌、抗病毒等作用,近年来研究发现其具明显抗肿瘤作用且毒副作用较低而备受关注。该文根据近5年来对大黄素抗肿瘤作用的研究,主要从抑制肿瘤生长、抑制迁移侵袭、联合用药增强疗效、辅佐化疗增敏减毒4个方面论述,以期为进一步研究提供参考。 |
| 关 键 词： | 大黄素 抗肿瘤 机制 |
| 收稿时间： | 2015-05-10 |
Research progress in anti-tumor effect of emodin |
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| LIN Wan-fu,WANG Chen and LING Chang-quan. Research progress in anti-tumor effect of emodin[J]. China Journal of Chinese Materia Medica, 2015, 40(20): 3937-3940 | |
| Authors: | LIN Wan-fu WANG Chen LING Chang-quan |
| Affiliation: | Changhai Hospital, The Second Military Medical University, Shanghai 200433, China,Changhai Hospital, The Second Military Medical University, Shanghai 200433, China and Changhai Hospital, The Second Military Medical University, Shanghai 200433, China |
| Abstract: | Emodin is one of the main active ingredient of Rheum palmatum, and has anti-inflammatory, anti-bacterial, anti-viral and other effects. In recent years, it arouse concern since it has a significant anti-tumor effect with low toxicity. In this paper we mainly report the anti-cancer effects of emodin according to the studies of the past five years, including four parts such as inhibit tumor growth, inhibit migration and invasion, enhance the efficacy of combination therapy, increase chemosensitivity and attenuated side effects. We hope that our work may provide a reference for further study. |
| Keywords: | emodin anti-cancer mechanisms |