不同生长期丹参茎叶及花序中丹酚酸类化学成分的分布与积累动态分析评价 Distribution of salvianolic acids in aerial parts of <i>Salvia</i> <i>miltiorrhiza</i> during different growing periods and accumulation dynamic analysis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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不同生长期丹参茎叶及花序中丹酚酸类化学成分的分布与积累动态分析评价

引用本文：	沙秀秀,宿树兰,沈飞,江曙,严辉,郭盛,钱大玮,段金廒.不同生长期丹参茎叶及花序中丹酚酸类化学成分的分布与积累动态分析评价[J].中草药,2015,46(22):3414-3419.

作者姓名：	沙秀秀宿树兰沈飞江曙严辉郭盛钱大玮段金廒

作者单位：	南京中医药大学江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏南京 210023;江苏大学药学院, 江苏镇江 212013;南京中医药大学江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏南京 210023;江苏大学药学院, 江苏镇江 212013;南京中医药大学江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏南京 210023;江苏大学药学院, 江苏镇江 212013;南京中医药大学江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏南京 210023;南京中医药大学江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏南京 210023;南京中医药大学江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏南京 210023;南京中医药大学江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏南京 210023;南京中医药大学江苏省中药资源产业化过程协同创新中心中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏南京 210023

基金项目：	江苏高校中药资源产业化过程协同创新中心建设专项(2013年度);江苏省“333高层次人才工程”第一层次培养对象资助项目(2013年度);江苏省高校中药学优势学科II期建设项目(ysxk-2014)

摘要：	目的对丹参地上茎叶、花序中7种丹酚酸类化学成分进行分析与评价,并探讨其在丹参植物生长过程中的动态积累规律,以期挖掘丹参地上部分的资源化利用价值与产业化开发前景。方法采用UPLC-TQ/MS联用技术,以Acquity UPLC BEH C18为色谱柱;乙腈-0.1%甲酸水为流动相,梯度洗脱,体积流量为0.4 m L/min,柱温35℃,质谱采用正、负离子模式电离,多反应检测(MRM)方式,对7种丹参酚酸类化学成分进行分析与检测。结果丹参茎叶中含有丰富的水溶性丹酚酸类化学成分,但未检测到脂溶性的丹参酮类成分;不同生长期丹参茎叶中酚酸类化学成分的量差异较大,除丹酚酸A外,各酚酸类成分量均在7~8月积累量达到最高值,以后逐渐降低。丹参花序中的丹参酚酸类成分总量在花盛期达到峰值,其在达到花盛期前动态变化趋势不明显,但当花冠进入凋萎期时,丹酚酸类成分量急剧下降。结论丹参非传统药用部位茎叶及花序中含有丰富的水溶性丹酚酸类资源性化学成分,尤其是迷迭香酸和丹酚酸B量较高,生长茂盛期其酚酸类成分的总量明显高于丹参根及根茎中的量。因此,丹参茎叶、花序可作为获取丹酚酸类化学物质的重要原料资源。
关键词：	丹参丹参茎叶丹参花序生长期丹酚酸类积累动态原儿茶醛咖啡酸丹参素丹酚酸A 阿魏酸迷迭香酸丹酚酸B
收稿时间：	2015/6/11 0:00:00
*Distribution of salvianolic acids in aerial parts of Salvia* miltiorrhiza during different growing periods and accumulation dynamic analysis**

SHA Xiu-xiu,SU Shu-lan,SHEN Fei,JIANG Shu,YAN Hui,GUO Sheng,QIAN Da-wei and DUAN Jin-ao.Distribution of salvianolic acids in aerial parts of Salvia miltiorrhiza during different growing periods and accumulation dynamic analysis[J].Chinese Traditional and Herbal Drugs,2015,46(22):3414-3419.

Authors:	SHA Xiu-xiu SU Shu-lan SHEN Fei JIANG Shu YAN Hui GUO Sheng QIAN Da-wei and DUAN Jin-ao

Institution:	Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;School of Pharmacy, Jiangsu University, Zhenjiang 212013, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;School of Pharmacy, Jiangsu University, Zhenjiang 212013, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;School of Pharmacy, Jiangsu University, Zhenjiang 212013, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China

Abstract:

Keywords:	Salvia miltiorrhiza Bge stems and leaves of Salvia miltiorrhiza inflorescence of Salvia miltiorrhiza growing time salvianolic acids accumulation dynamic protocatechuic aldehyde caffeic acid tanshinol salvianolic acid A ferulic acid rosmarinic acid salvianolic acid B
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