| 合成鱼腥草素对小鼠免疫功能的影响 |
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| 引用本文： | 邵兰,于庆海,吴红艳,李霞.合成鱼腥草素对小鼠免疫功能的影响[J].沈阳药科大学学报,1999,16(3):209-211. |
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| 作者姓名： | 邵兰 于庆海 吴红艳 李霞 |
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| 作者单位： | 沈阳药科大学中药系,沈阳,110015 |
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| 摘 要： | 对于脾切除致免疫功能低下小鼠，合成鱼腥草素（ＨＯＵ）６０ｍｇ／ｋｇ，１２０ｍｇ／ｋｇ灌胃给药均能增强其腹腔巨噬细胞的吞噬功能（Ｐ＜０００１）；迟发型超敏反应强度（Ｐ＜０００１）；明显提高血清溶血素水平（Ｐ＜００５；Ｐ＜０００１）；外周血淋巴细胞ＡＮＡＥ阳性百分率（Ｐ＜０００１）；ＨＯＵ６０ｍｇ／ｋｇ还能明显提高脾切小鼠腹股沟淋巴结中淋巴细胞个数（Ｐ＜００１），表明ＨＯＵ对脾切除致免疫功能低下小鼠的特异性、非特异性免疫功能均有明显增强作用．
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| 关 键 词： | 合成鱼腥草素 脾切除 免疫增强 |
| 修稿时间： | :1999-02-0 |
The Effects of Houttuyninum on Immunologic Function of Splenectomized Mice |
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| Shao Lan,Yu Qinghai,Wu Hongyan,Li Xia.The Effects of Houttuyninum on Immunologic Function of Splenectomized Mice[J].Journal of Shenyang Pharmaceutical University,1999,16(3):209-211. |
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| Authors: | Shao Lan Yu Qinghai Wu Hongyan Li Xia |
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| Abstract: | For the immunodeficiency mice following splenectomy,houttuyninum ig 60 mg/kg,120 mg/kg strikingly strengthened the phagocytosing function of the peritoneal macrophage system (P<0001),delayed the type hypersensitivity (DTH)reaction (P<0001);significantly enhanced the level of serumhemolysin(P<005;P<001),and ANAE( ) cell percentage of peripheral blood lymphocytes(P<0001)furthermore,60 mg/kg remarkably raised the amount of lymphocytes of groin lymph node(P<005).These experimental results of hottnyninum were suggested that houttuyninum could obviously strengthen the nonspecific and sepecific immune function in splenectomized mice. |
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| Keywords: | houttuyninum splenectomy immunoenhancement |
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