| 经垂直传播的乙型肝炎病毒肝外定位与意义 |
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| 引用本文： | 王珊珊,彭桂福,姜普林,曾年华,王志斌. 经垂直传播的乙型肝炎病毒肝外定位与意义[J]. 现代预防医学, 2001, 28(3): 267-268 |
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| 作者姓名： | 王珊珊 彭桂福 姜普林 曾年华 王志斌 |
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| 作者单位： | 广州军区军事医学研究所 |
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| 摘 要： | 目的：研究乙型肝炎病毒（HBV）的子宫内传播率与受染子的HBV的肝外定位。方法：选择25名女性HBV携带得与其终止妊娠的胎儿为研究对象，应用HBVS基因与C基因引物，以巢式PCR检测HBV DNA。结果：25名女性携带者的胎儿中10例发生HBV的子宫内传播，传播率为40．0％，受染子代的肝外HBV DNA检出率以白细胞为最高，其次脾脏、肺脏、心脏，此外从肾脏、脐带、皮肤、肌肉等多种组织、器官也可检出，结论：HBV可在肝外多种组织，器官定位，肝外定位可能对病毒的保存起一定作用。
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| 关 键 词： | 乙型肝炎病毒 垂直传播 乙型肝炎 流行病学 |
| 文章编号： | 1003-8507(2001)03-0267-02 |
| 修稿时间： | 2000-11-25 |
THE SIGNIFICANCE AND DETECTION OF HEPATITIS B VIRUS IN TISSUES OUT OF LIVER BY THE VERTICAL TRANSMISSION |
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| WANG Shan shan,PENG Gui fu,JIAN Pu lin,et al.. THE SIGNIFICANCE AND DETECTION OF HEPATITIS B VIRUS IN TISSUES OUT OF LIVER BY THE VERTICAL TRANSMISSION[J]. Modern Preventive Medicine, 2001, 28(3): 267-268 |
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| Authors: | WANG Shan shan PENG Gui fu JIAN Pu lin et al. |
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| Affiliation: | WANG Shan shan,PENG Gui fu,JIAN Pu lin,et al.Institute of Military Medicine,Guangzhou Command PLA,Guangzhou 510507. |
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| Abstract: | Objective:The study was carried out,to study transmission of HBV in womb and HBV in tissues out of liver.Methods:The study contained 25 HBV women carriers and their foetus.HBV DNA was detected by nest PCR and the primers were from HBV S gene,C gene.Results:10 of 25 foetus were infected,the rate of HBV transmission in womb was 40 0%.HBV DNA was detected in peripheral blood leukocyte,spleen,lung,heart,kidney,umbilical cord,skin,muscular,etc.The rate of HBV detected in peripheral blood leukocyte was more high than other tissues.Conclusion:HBV may be detected in varied tissues or organs.HBV in tissues out of liver may be helpful to preserve virus. |
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| Keywords: | Hepatitis B virus Vertical transmission |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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