孕早期感冒或发热与常见体表出生缺陷关系的病例对照研究

一些研究表明孕早期感冒或发热与某些出生缺陷的发生有关1~6]。中国北方地区是体表重大出生缺陷高发的地区,同时由于气候寒冷,也是感冒或发热高发的地区。因此,研究感冒或发热与出生缺陷危险性的关系,对于有效预防和控制出生缺陷具有重要意义。山西省属于我国乃至世界上体表出

Maternal cold or fever and the risk of common external birth defects: a case-control study in Shanxi Province, China

Objective To explore the relation between maternal cold or fever during early pregnancy and risk of the three types of common external structural birth defects, neural tube defects, cleft lip or palate and limb birth defects. Methods Data was derived from a population-based case-control study on birth defects in Shanxi province. The subjects included in this study were 447 common birth defects cases (326 cases of neural tube defects, 63 cleft lip or palate and 58 limb birth defects) ascertained during Jan 2003 and Jun 2005 in study areas and 505 normal controls randomly selected in similar residence during same period as cases. Results The risks of having a baby with neural tube defects, cleft lip or palate or limb birth defects were respectively 4.09 (95 % CI =2.64-6.32), 3.04 (5 % CI=1.48-6.26) and 1.37 (95 % CI=0.57-3.32) for mothers with cold or fever history during early pregnant period. Conclusion Maternal cold or fever during early pregnancy markedly increased the risk of offspring's neural tube defects and orofacial cleft, and was not significantly associated with the risk of offspring's limb birth defects.