血清和肽素在老年慢性心力衰竭患者诊断及治疗中的作用

目的探讨血清和肽素水平与老年慢性心力衰竭之间的关系。方法选取并45例老年慢性心力衰竭患者(HF组)、45名健康对照者(对照组),对其血清和肽素和氨基末端B型钠尿肽原(NT-pro BNP)水平进行检测。HF组患者按美国纽约心脏病学会(NYHA)心功能分级标准,分为NYHⅢ级者20例、NYHAⅣ级者25例。测定左室射血分数(LVEF)和左室舒张末期内径(LVEDD)值,并进行比较分析。结果 HF组患者血清和肽素和NT-pro BNP水平明显高于对照组,并随NYHA分级的增加而升高(P<0.01)。结论 copeptin水平可作为老年慢性心力衰竭患者临床诊断、评估病情的一个可靠指标。

Application of serum and copeptin in diagnosis and treatment of elderly patients with chronic heart failure

Objective This study assessed copeptin concentrations in elderly patients with chronic heart failure of different levels and their relationships. Methods Totally 45 elderly patients with chronic HF( HF) and 45 healthy control subjects( control group) were in-cluded in this analysis. Copeptin and N-terminal prohormone B-type natriuretic peptide( NT-proBNP) were performed by a core labora-tory. 45 cases of senile patients with chronic heart failure were classified into 2 groups by United States New York Heart Association (NYHA)cardiac functional grading standards. They were divided into NYH Ⅲ group of 20 cases,NYHA Ⅳ group of 25 cases. Left ventricular ejection fraction( LVEF) and left ventricular end diastolic diameter( LVEDD) value were compared between them. Results In HF group,copeptin and NT-proBNP levels were significantly higher than those in control group and their levels were increased with increasing severity of disease,as classified by NYHA classification(P<0. 01). Conclusion Copeptin can be used as a reliable indi-cator in clinical diagnosis,assessment of severity of patients with chronic heart failure.