| 慢性肾衰血友病因子抗原和纤溶酶原激活物变化的研究 |
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| 引用本文： | 孙奉劼.慢性肾衰血友病因子抗原和纤溶酶原激活物变化的研究[J].右江医学,2004,32(4):312-313. |
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| 作者姓名： | 孙奉劼 |
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| 作者单位： | 南京医科大学附属南京第一医院检验科,江苏,南京,210006 |
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| 摘 要： | 目的 探讨慢性肾衰患者 (CRF)的血管性血友病因子抗原 (vWF :Ag)和组织型纤溶酶原激活物 (t PA)的变化。 方法 收集慢性肾衰患者血清 3 8份 (观察组 ) ,健康体检血清 3 8份 (对照组 ) ,用固相酶联免疫吸附法检测血清中vWF :Ag和t PA并比较其结果。结果 观察组的vWF :Ag浓度较对照组显著升高 (P <0 .0 1) ,而t PA显著降低 (P <0 .0 1)。结论 vWF :Ag和t PA都在内皮细胞内合成并释放入血 ,慢性肾衰患者 (CRF)中两者均异常 ,表明血管内皮损伤是慢性肾衰患者 (CRF)血栓前状态的重要原因
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| 关 键 词： | 慢性肾功能衰竭 血管性血友病因子抗原(vWF:Ag) 组织型纤溶酶原激活物(t-PA) |
| 文章编号： | 1003-1383(2004)04-312-02 |
| 修稿时间： | 2004年6月10日 |
The Study to The Level of vWF:Ag and t-PA in CRF |
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| SUN Feng,jie.The Study to The Level of vWF:Ag and t-PA in CRF[J].Youjiang Medical Journal,2004,32(4):312-313. |
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| Authors: | SUN Feng jie |
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| Abstract: | Objective To explore the change of antigen level of von Willebrand Factor (vWF:Ag) and tissue plasminogen activator in old people with CRF and in the controls groups.Methods 38 cases of CRFand 38 cases in the control group all underwent measuring vWF:Ag and t PA by ELISA, and the results were campared . Results The level of vWF:Ag were significantly increased (P<0.05), and the level of t PA were decreased (P<0.05) in CRF. Conclusion The results showed that the injury of vascular endothelium was an important element of the prethrombotic state of CRF in old people. |
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| Keywords: | CRF The injury of vascular endothelium vWF:Ag t-PA |
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