门诊森田疗法合用文拉法辛治疗强迫症的对照研究

目的探讨门诊森田疗法与文拉法辛联合治疗强迫症的效果及安全性。方法将68例强迫症病人随机分为观察组和对照组，每组34例。观察组采用森田疗法和文拉法辛治疗，对照组单纯以文拉法辛治疗，疗程3个月。采用耶鲁一布朗强迫症状量表（Y—BOCS）、汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）和副反应量表（TEss）评定疗效及安全性。结果在治疗4、8、12周末，观察组Y—BOCS、HAMA、HAMD量表评分均显著低于对照组（￡=2．026～4．378，P〈0．05）；两组不良反应比较差异无显著性（χ^2=0．087～0．405，P〉0．05）。结论门诊森田疗法与文拉法辛联合治疗强迫症的效果优于单用文拉法辛治疗。

A CONTROL STUDY OF MORITA THERAPY COMBINED WITH VENLAFAXINE IN THE TREATMENT OF OBSESSIVE-COM-PULSIVE DISORDER

Objective To evaluate the efficacy and safety of Morita therapy combined with venlafaxine for obsessive-com- pulsive disorder （OCD）. Methods Sixty-eight patients with OCD were equally randomized to observation group and control group. The patients in observation group were treated with combined Morita therapy with venlafaxine, and those in the control group were treated with venlafaxine alone, the course of treatment was three months for both groups. The efficacy and safety were assessed using Y BOCS, HAMA,HAMD and TESS scales. Results The scores of Y-BOCS, HAMA and HAMD scales in ob- served group were significantly lower than that in control group at the end of 4, 8 and 12 weeks after the treatment （t=2. 026- 4. 378,P〈0.05）. There was no significant difference between the two groups in terms of side effects （χ^2= 0. 087-0. 405,P〉 0.05）. Conclusion The combination of Morita therapy and venlafaxine is superior than venlafaxine monotherapy for OCD.