| 甲状腺肿瘤的分子生物学进展 |
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| 引用本文： | 姚晓虹. 甲状腺肿瘤的分子生物学进展[J]. 上海交通大学学报(医学版), 2006, 26(5): 439-443 |
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| 作者姓名： | 姚晓虹 |
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| 作者单位： | 上海交通大学医学院新华医院病理科,上海,200029 |
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| 摘 要： | 近年来,分子生物学的理论和技术在内分泌肿瘤的诊断和研究方面,特别是甲状腺肿瘤方面取得了一系列的进展。研究表明,甲状腺肿瘤内存在端粒酶活性的异常增高;存在十多种已知基因,如Ret、Ras、Fos、TKs、p16、p27、p53和M asp in等突变;和一些特殊蛋白的改变,如生长因子、血管内皮生长因子、细胞周期蛋白等分子生物学方面的改变。这些甲状腺肿瘤相关的分子生物学变化不仅对甲状腺肿瘤的形成、发展和转移起着重要的作用,也与肿瘤的诊断和预后判断有着十分密切的关系。
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| 关 键 词： | 甲状腺肿瘤 分子生物学 端粒酶 基因 转移 |
| 文章编号： | 0258-5898(2006)05-0439-05 |
| 收稿时间： | 2006-02-23 |
| 修稿时间： | 2006-02-23 |
Progress of Molecular Biology in Thyroid Tumor |
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| YAO Xiao-hong. Progress of Molecular Biology in Thyroid Tumor[J]. Journal of Shanghai Jiaotong University:Medical Science, 2006, 26(5): 439-443 |
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| Authors: | YAO Xiao-hong |
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| Affiliation: | Department of Pathology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China |
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| Abstract: | In recent years,there have been a series of development in molecular biological theory and technology for the diagnosis and research of endocrine tumors,especially for thyroid tumor.It is indicated that in thyroid tumor there are abnormally high activity of telomerase,mutation of several known genes such as Ret,Ras,Fos,Tks,p16,p27,p53,Maspin,etc,and changes in specific protein such as GF,VEGF,Cyclin,etc.These molecular biological changes in thyroid tumor not only play a part in the genesis,development and metastasis,but also closely relate to the diagnosis and prognosis. |
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| Keywords: | thyroid tumor molecular biology telomerase gene metastasis |
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