男性2型糖尿病患者25羟基维生素D的水平变化

目的探讨男性2型糖尿病(T2DM)患者血清25羟基维生素D水平的变化。方法选择男性T2DM患者87例为病例组,同期男性健康体检者90名为正常对照组。用酶联免疫法(ELISA)检测各组血清25羟基维生素D水平及相关临床和生化指标。结果①T2DM组血清25羟基维生素D水平为(9.88±3.74)ng/mL,正常对照组为(12.38±3.51)ng/mL,T2DM组25羟基维生素D水平明显低于对照组(P<0.05);②将血清25羟基维生素D与临床生化指标进行相关性分析,T2DM组血清25羟基维生素D水平与体重指数(r=0.230)和血钙(r=0.257)正相关,与肌酐负相关(r=-0.245);③T2DM组空腹血糖(FBG)显著高于正常对照组(9.08±3.52)vs(4.55±0.46)mmol/L,P<0.05),高密度脂蛋白胆固醇显著低于正常对照组(1.06±0.28)vs(1.40±0.55)mmol/L,P<0.05)。余临床生化指标无统计学差异。结论男性2型糖尿病患者血清25羟基维生素D水平明显降低,血清25羟基维生素D水平与体重指数、血钙正相关,与肌酐负相关,及时补充维生素D应成为2型糖尿病患者众多治疗手段之一。

The change of 25-hydroxyvitamin D level in type 2 diabetes male patients

【Objective】To investigate the serum changes of 25-hydroxyvitamin D level from the male patients with type 2 diabetes.【Methods】87 male patients with type 2 diabetes mellitus were selected as the case group,and 90 male healthy people were selected as the control group.ELISA was used for the detection of serum 25-hydroxyvitamin D,【Resluts】1.Serum 25-hydroxyvitamin D level of T2DM group significantly lower than those of the control group（P ＆lt; 0.05）.2.Serum 25-hydroxyitamin D level in T2DM group was positive correlation with body mass index（r = 0.230） and calcium（r = 0.257）,and negative correlation with creatinine（r =-0.245）.3.Compared with control group,fasting blood glucose（FBG） in T2DM group was significantly higher（9.08±3.52）mmol/L vs（4.55±0.46）mmol/L,P ＆lt; 0.05）,high-density lipoprotein cholesterol was significantly lower（1.06±0.28）mmol/L vs（1.40±0.55）mmol/L,P ＆lt; 0.05）.【Conclusion】Serum 25-hydroxyvitamin D in male patients with type 2 diabetes was significantly lower than that of control group and serum 25-hydroxyitamin D was positively correlated with body mass index,blood calcium and negatively correlated with creatinine.