Severe autoimmune neutropenia and thrombopenia associated with chronic C hepatitis: effect of antiviral therapy |
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| Authors: | d'Alteroche Louis Assor Philippe Lefrou Laurent Senecal Delphine Gaudy Catherine Bacq Yannick |
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| Affiliation: | 1. Service d’Hépato-Gastroentérologie, Hôpital Trousseau, 37 044 Tours Cedex;2. Service d’Oncologie médicale, Hôpital Bretonneau, 37 044 Tours Cedex;3. Laboratoire de Virologie, Hôpital Bretonneau, 37 044 Tours Cedex;1. Department of Biomedical, Biotechnological and Translational Sciences (S.Bi.Bi.T.), Anatomy & Histology Unit, University of Parma, Via Gramsci 14, 43126 Parma, Italy;2. Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43126 Parma, Italy;3. Department of Clinical Sciences Sec. Internal Medicine and Critical Long-Term Care University Hospital, Via Gramsci 14, 43126 Parma, Italy;1. Division of Hematology/Oncology, Tisch Cancer Institute, Myeloproliferative Disorders Research Consortium, Mount Sinai School of Medicine, New York, NY;2. Division of Hematology/Oncology, Tisch Cancer Institute, Myeloproliferative Disorders Research Consortium, Mount Sinai School of Medicine, New York, NY;3. Division of Hematology/Oncology, Tisch Cancer Institute, Myeloproliferative Disorders Research Consortium, Mount Sinai School of Medicine, New York, NY;4. Department of Pathology, Mount Sinai School of Medicine, New York, NY;5. Geisinger/Hazleton Cancer Center, Hazleton, PA;6. Division of Hematology/Oncology, Tisch Cancer Institute, Myeloproliferative Disorders Research Consortium, Mount Sinai School of Medicine, New York, NY;7. Department of Pathology and Division of Hematology/Oncology, Tisch Cancer Institute, Myeloproliferative Disorders Research Consortium, Mount Sinai School of Medicine, New York, NY;1. Department of Pathology, The Methodist Hospital, Houston, TX;2. Department of Pathology, The Methodist Hospital, Houston, TX;3. Department of Internal Medicine, The Methodist Hospital, Houston, TX;1. CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN;1. SAN RAFFAELE SCIENTIFIC INSTITUTE;;2. UNIVERSITÀ VITA-SALUTE SAN RAFFAELE;1. Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA |
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| Abstract: | ![]()
We report the case of a 45-year-old man admitted for severe autoimmune thrombopenia and neutropenia associated with chronic viral C hepatitis. After failed, intravenous gammaglobulin and corticosteroid therapy antiviral treatment with interferon and ribavirin was given for one year. Thrombopenia improved progressively during antiviral therapy and worsened after the end of treatment. Neutropenia improved during antiviral therapy. Two years after the end of treatment, serum RNA-HCV was positive, white cell count was normal and platelet count was 77 G/L. In conclusion, these results suggest that antiviral therapy may be useful in patients with auto-immune cytopenia associated with viral hepatitis C infection. |
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